High frequency of HLA-B27 and Reiter's syndrome in Navajo Indians.

Autor: Morse HG, Rate RG, Bonnell MD, Kuberski T
Jazyk: angličtina
Zdroj: The Journal of rheumatology [J Rheumatol] 1980 Nov-Dec; Vol. 7 (6), pp. 900-2.
Abstrakt: Eighteen cases of Reiter's syndrome were found in a population of approximately 6,000 Navajo Indians. The phenotype frequency of HLA-B27 in this population was found to be 36%. The area in which these people live is endemic for shigellosis, Shigella flexneri being the most common species isolated. Presumably the high frequency of HLA-B27 and shigella infections account for the high incidence and prevalence of Reiter's syndrome in this population.
Databáze: MEDLINE