| Autor: |
Reebye PN, Yiptong C, Samsoon J, Schulsinger F, Fabricius J |
| Jazyk: |
angličtina |
| Zdroj: |
Pharmacopsychiatria [Pharmacopsychiatria] 1982 Sep; Vol. 15 (5), pp. 164-9. |
| DOI: |
10.1055/s-2007-1019531 |
| Abstrakt: |
The new selective serotonin (5-HT)-uptake inhibitor femoxetine was compared with amitriptyline in a double-blind clinical trial comprising 77 depressed patients. The depressive symptoms were evaluated with the Hamilton rating scale, and a global clinical evaluation. Both drugs showed an antidepressive effect and no significant differences were found. Femoxetine induced a significantly lower frequency of dry mouth and blurred vision; this difference is presumably due to the weak anticholinergic effect of this substance. A small but significant weight loss was observed in the femoxetine group but not in the amitriptyline group. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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