| Autor: |
Takeda A, Goto R, Tamemasa O, Chaney JE, Digenis GA |
| Jazyk: |
angličtina |
| Zdroj: |
Radioisotopes [Radioisotopes] 1984 Apr; Vol. 33 (4), pp. 213-7. |
| DOI: |
10.3769/radioisotopes.33.4_213 |
| Abstrakt: |
Based on the high radioactivity uptake of some 14C-labeled D-amino acids in tumors and pancreas of mice, this investigation was undertaken to ascertain possible usefulness of radioactive D-methionine as a nuclear imaging agent. Radioactivity derived from D-[3,4-14C]-methionine in Ehrlich solid tumor was approximately three times higher than that from the L-isomer, but was the same as for mouse pancreas. Excretion rate of the radioactivity of D-[14C]-methionine into urine was approximately two times faster than that of the L-isomer. As compared with two potential imaging agents, 1-aminocyclopentane-1-carboxylic acid and alpha-aminoisobutyric acid, D-methionine showed almost the same radioactivity biodistribution in tumor and pancreas. These results suggest potential for D-methionine as a mother compound for use in tumor and pancreas imaging. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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