| Autor: |
ElSohly MA, Harland EC, Benigni DA, Waller CW |
| Jazyk: |
angličtina |
| Zdroj: |
Current eye research [Curr Eye Res] 1984 Jun; Vol. 3 (6), pp. 841-50. |
| DOI: |
10.3109/02713688409000797 |
| Abstrakt: |
Thirty-two different cannabinoids were tested for their ability to reduce intraocular pressure (IOP) in the rabbit. These included many of delta 9- and delta 8-THC derivatives and metabolites along with other natural and synthetic cannabinoids. In addition, some non-cannabinoid constituents of Cannabis were screened using the same model. All compounds were administered intravenously, while only a few were tested topically in mineral oil. Water soluble derivatives of delta 9- and delta 8-THC were prepared and tested topically in aqueous solution. The data revealed that certain derivatives of delta 9-and delta 8-THC were more active in lowering IOP than the parent cannabinoids. In addition, compounds other than delta 9- and delta 8-THC and their derivatives were shown to have activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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