Combination chemotherapy with VM-26, adriamycin bleomycin, and prednisone as a secondary treatment of malignant lymphoma.

Autor: Goldhirsch A, Pirovino M, Sonntag RW, Tschopp L, Ryssel HJ, Brunner KW
Jazyk: angličtina
Zdroj: Cancer treatment reports [Cancer Treat Rep] 1980 Feb-Mar; Vol. 64 (2-3), pp. 335-7.
Abstrakt: Thirty-eight pretreated patients with Hodgkin's disease (HD) and malignant non-Hodgkin's lymphoma were given combination chemotherapy with VM-26, Adriamycin, bleomycin, and prednisone. Four of 15 evaluable patients with HD achieved a partial remission (PR), with a median duration of 8 months. Of 12 patients with diffuse poorly differentiated lymphocytic lymphoma, one achieved a complete remission (30+ months) and five achieved a PR (median, 6 months). One of three patients with histiocytic lymphoma had a PR of 1.5 months. There was one drug-related death. Five patients developed life-threatening hematologic toxicity. Two HD responders died of acute nonlymphocytic leukemia.
Databáze: MEDLINE