| Autor: |
Brady SF, Cochran DW, Nutt RF, Holly FW, Bennett CD, Paleveda WJ, Curley PE, Arison BH, Saperstein R, Veber DF |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of peptide and protein research [Int J Pept Protein Res] 1984 Feb; Vol. 23 (2), pp. 212-22. |
| DOI: |
10.1111/j.1399-3011.1984.tb02712.x |
| Abstrakt: |
A cyclic hexapeptide analog of somatostatin, cyclo-(Pro-delta z-Phe-D-Trp-Lys-Thr-Phe) (II) has been synthesized by a combination of solid phase and solution methodology. It shows a potency for inhibition of growth hormone release in vitro about one-tenth that of the corresponding saturated analog, cyclo-(Pro-Phe-D-Trp-Lys-Thr-Phe) (I). N.m.r. studies indicate comparable backbone conformations for analogs I and II. However, the sum of our findings from biological evaluation and solution physical data suggest that on the receptor the position-7 phenyl ring of I is adopting a conformation which differs from that of one of the major solution conformers defined previously by n.m.r. studies. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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