| Autor: |
Wajchenberg BL, Cesar FP, Leme CE, Borghi VC, Souza VC, Souza IT, Neto DG, Germek OA, Coy DH, Comaru-Schally AM, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme [Horm Metab Res] 1983 Oct; Vol. 15 (10), pp. 471-4. |
| DOI: |
10.1055/s-2007-1018762 |
| Abstrakt: |
Two analogs of somatostatin (Ala2,D-Trp8,D-Cys14-Somatostatin and L-5F-Trp8-Somatostatin) infused into acromegalics at the rate of 4.5 micrograms/min suppressed arginine-stimulated growth hormone release more strongly than 6 micrograms/min somatostatin (110 +/- 11% and 129 +/- 14%, respectively). Under the same conditions the two somatostatin analogs induced a much smaller inhibition of insulin (33 +/- 13% and 44 +/- 18%) and glucagon (28 +/- 10% and 45 +/- 17%, respectively) release than somatostatin did. Somatostatin analogs with dissociated actions could be promising for the treatment of diseases such as acromegaly, diabetes mellitus and some ectopic hormone syndromes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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