Reduced fecundity of vitamin D deficient rats.

Autor: Hickie JP, Lavigne DM, Woodward WD
Jazyk: angličtina
Zdroj: Comparative biochemistry and physiology. A, Comparative physiology [Comp Biochem Physiol A Comp Physiol] 1983; Vol. 74 (4), pp. 923-5.
DOI: 10.1016/0300-9629(83)90370-5
Abstrakt: 1. Female rats fed on a vitamin D deplete (D-) diet for 90 days prior to mating gave birth to litters having significantly fewer young than females fed a diet containing vitamin D (2.2 IU/g, D + diet). 2. Neither age nor body weight of females had a significant influence on litter size. 3. Serum calcium and phosphorus levels in D+ and D- dams were not significantly different, nor were serum calcium and phosphorus levels and bone ash of D+ and D- weanlings. 4. The level of 25-hydroxyvitamin D3 [25(OH)D3], the main circulating form of vitamin D, was low in D- dams and was not detected in D- weanlings. 5. These data suggest that vitamin D is required for reproduction in the rat.
Databáze: MEDLINE