| Autor: |
Walker M, Litherland HK, Murphy J, Smith JA |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of hospital infection [J Hosp Infect] 1984 Dec; Vol. 5 Suppl A, pp. 101-6. |
| DOI: |
10.1016/0195-6701(84)90039-2 |
| Abstrakt: |
An unacceptably high infection rate in patients undergoing vascular surgery prompted two studies on these patients. The first study confirmed the problem and described antibiotic usage which was not standardized. A second double blind randomized study compared antibiotic usage in two groups of patients, receiving vein grafts or synthetic grafts. Patients receiving vein grafts were randomized either to placebo or cefazolin 2 g 1 h pre-operatively and every 6 h for 48 h. Patients receiving synthetic grafts were randomized either to cefazolin 1 g or to cefazolin 2 g 1 h pre-operatively and every 6 h for 48 h. Four of 50 vein graft patients developed a purulent discharge. Two of these infected patients received placebo and two received the cefazolin 2 g protocol. Of 90 patients receiving a synthetic graft, four became infected. Three patients were randomized to the cefazolin 1 g protocol and one to the cefazolin 2 g protocol. No statistically significant differences were observed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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