Generic propoxyphene: need for clinical bioavailability evaluation.

Autor: DeSante KA, Stoll RG, Kaiser DG, DiSanto AR
Jazyk: angličtina
Zdroj: Journal of pharmaceutical sciences [J Pharm Sci] 1977 Dec; Vol. 66 (12), pp. 1713-6.
DOI: 10.1002/jps.2600661214
Abstrakt: Plasma level data on two investigational capsule formulations of propoxyphene with similar physicochemical parameters demonstrate that the formulations have different in vivo bioavailabilities. The potential bioavailability problems with water-soluble drugs and the lack of correlation of in vitro and in vivo parameters for equivalent drug formulations are discussed.
Databáze: MEDLINE