| Autor: |
Poonian MS, McComas WW, Kramer MJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1979 Aug; Vol. 22 (8), pp. 958-62. |
| DOI: |
10.1021/jm00194a014 |
| Abstrakt: |
Synthesis of four arabinofuranosyl derivatives of the antitumor agent 3-deazaguanine is described. By the use of 13C and 1H nuclear magnetic resonance spectroscopy, the structures of these nucleosides were established to be alpha and beta pairs of N-7 and N-9 arabinosides of 3-deazaguanine. In contrast to 3-deazaguanine and its ribosyl derivative, the nucleosides described in this paper were found to be inactive against Sarcoma 180 in mice at 100 mg/kg. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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