[Circadian fluctuations in dioxidine toxicity].

Autor: Gus'kova TA, Liberman SS
Jazyk: ruština
Zdroj: Farmakologiia i toksikologiia [Farmakol Toksikol] 1985 Jan-Feb; Vol. 48 (1), pp. 80-2.
Abstrakt: It has been established in rat experiments that toxicity of the antibacterial drug dioxydin (1,4-di-N-oxide 2,3-dioxymethylquinoxaline) depends on the time of administration. The drug exhibits the minimal and maximal toxicity upon administration at 8 o'clock p.m. and at 12 o'clock, respectively.
Databáze: MEDLINE