Polyarteritis nodosa presenting with severe upper gastrointestinal bleeding: a case report.

Autor: Xiao XY; Department of Rheumatology, China-Japan Friendship Hospital, Beijing, 100029, China., Niu Y; Department of Pathology, China-Japan Friendship Hospital, Beijing, 100029, China., Liu PP; Department of Pathology, China-Japan Friendship Hospital, Beijing, 100029, China., Zheng YM; Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing, 100029, China., Zhang MG; Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, China., Wang GC; Department of Rheumatology, China-Japan Friendship Hospital, Beijing, 100029, China., Wang XD; Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, China., Liu F; Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, China. fangliu873@yahoo.com.
Jazyk: angličtina
Zdroj: Journal of medical case reports [J Med Case Rep] 2024 Dec 21; Vol. 18 (1), pp. 616. Date of Electronic Publication: 2024 Dec 21.
DOI: 10.1186/s13256-024-04892-7
Abstrakt: Background: Polyarteritis nodosa is a relatively uncommon type of systemic necrotizing vasculitis that primarily affects medium-sized arteries. While gastrointestinal involvement is known in polyarteritis nodosa, heavy gastrointestinal bleeding due to gastric ulceration is relatively uncommon. We present the case of an 81-year-old male of Chinese ethnicity who experienced severe gastrointestinal bleeding as a result of polyarteritis nodosa and an innovative treatment approach for a better patient outcomes.
Case Presentation: Upon admission to the medical intensive care unit, the patient underwent a comprehensive diagnostic assessment, including examinations for cardiovascular and dermatological abnormalities, laboratory tests, autoantibody and tumor marker assessments, and imaging studies (such as endoscopies, whole-body computed tomography, and positron emission tomography-computed tomography scans), and a skin biopsy. The patient had tachycardia, hypotension, and extensive skin abnormalities on the lower extremities along with anemia, low platelets, and abnormal renal function. Upper gastrointestinal endoscopy revealed gastric and duodenal ulcers. Additional examinations, including electronic colonoscopy, capsule endoscopy, and whole-body computed tomography, were negative. A positron emission tomography-computed tomography scan showed increased uptake in the arterial walls and skin, which supported the diagnosis of polyarteritis nodosa, later confirmed by a biopsy of the skin on the lower extremities. Methylprednisolone, octreotide, and omeprazole were administered, leading to improvement in gastrointestinal symptoms, ulcer healing, and skin recovery. The patient continued with prednisone for 1 month.
Conclusion: This case serves to inform gastroenterologists about the need to consider polyarteritis nodosa in severe upper gastrointestinal bleeding and underscores the importance of prompt, medication-based treatment for successful patient outcome.
Competing Interests: Declarations. Ethics approval and consent to participate: No IRB is required for case reports and written informed consent was obtained. Consent for publication: Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Competing interests: Not applicable.
(© 2024. The Author(s).)
Databáze: MEDLINE
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