Sub-minimum inhibitory concentrations in ceftazidime exacerbate the formation of Acinetobacter baumannii biofilms.

Autor: Yadav B; Laboratory of Applied Microbiology and Cancer Remedies, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India 110067., Jaiswal A; Laboratory of Applied Microbiology and Cancer Remedies, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India 110067., Kumar D; Laboratory of Applied Microbiology and Cancer Remedies, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India 110067., Karad DD; Department of Microbiology, Shri Shivaji Mahavidyalaya, Barshi, India 413401., Joshi PR; Laboratory of Applied Microbiology and Cancer Remedies, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India 110067; Department of Chemistry, S. B. E. S. College of Sciences, Chattrapati Sambhajinagar, India 431001., Kamble DP; Department of Chemistry, S. B. E. S. College of Sciences, Chattrapati Sambhajinagar, India 431001., Mercier C; Translational Innovation in Medicine and Complexity (TIMC) Laboratory, Translational microbiology - Evolution - Engineering (TrEE) team, UMR5525 CNRS/Université Grenoble Alpes/VetAgro'Sup, Grenoble, France. Electronic address: corinne.mercier@univ-grenoble-alpes.fr., Kharat AS; Laboratory of Applied Microbiology and Cancer Remedies, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India 110067. Electronic address: arunkharat2007@gmail.com.
Jazyk: angličtina
Zdroj: Microbial pathogenesis [Microb Pathog] 2024 Dec 13, pp. 107229. Date of Electronic Publication: 2024 Dec 13.
DOI: 10.1016/j.micpath.2024.107229
Abstrakt: Associated with nosocomial infections, the environmental Gram-negative coccobacillus A. baumannii leads to various kinds of high mortality-rate infections among which pneumonias mainly in immune-compromised people from health-care facilities. A critical component of the current antibiotic resistance problem is the presence of antibiotics sub-minimum inhibitory concentrations (sub-MICs) in a variety of natural settings including drinking water, sewage water, rivers, lakes, and natural sludge. In India, third-generation cephalosporins such as ceftazidime (CAZ) count among the most often prescribed β-lactams to treat infections by A. baumannii. In this study, we showed that CAZ sub-MICs 1/ reduce adhesion to lung epithelial cells and slow down the growth of the A. baumannii KSK1 strain, which nevertheless quickly resumes its growth; 2/ alter the morphology of A. baumannii KSK1 planktonic cells and induce the formation of bacterial aggregates that resemble biofilms; 3/ increase the in vitro formation of biofilms by A. baumannii KSK1 bacterial cells. Our findings underscore the importance of considering sub-MICs in antibiotic therapy and environmental contamination as the antibiotics sub-MICs potentially found in wastewater may contribute to the selection causing antibiotic resistance and persistence of antibiotic-resistant strains.
Competing Interests: Declaration of Competing Interest The authors declare no competing interests.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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