Restless legs syndrome among blood donors: A systemic review and meta-analysis.

Autor: Ngoma AM; Centre intégré de santé et de services sociaux de l'Outaouais, Gatineau, Canada., Mutombo PB; Kinshasa School of Public Health, University of Kinshasa, Kinshasa, Democratic Republic of Congo., Mosli M; Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia., Omokoko MD; Department of Medicine, FMSS, Sherbrooke University, Quebec, Canada., Nollet KE; Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima, Japan., Ohto H; Radiation Medical Science Center for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.; Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima, Japan.
Jazyk: angličtina
Zdroj: Vox sanguinis [Vox Sang] 2024 Dec 10. Date of Electronic Publication: 2024 Dec 10.
DOI: 10.1111/vox.13780
Abstrakt: Background and Objectives: Restless legs syndrome (RLS), with adverse health outcomes, has been linked to blood donation, but evidence published thus far has not been rigorously analysed. This systematic review aggregates existing evidence on RLS among blood donors and identifies associated factors worthy of further investigation.
Materials and Methods: MEDLINE and EMBASE were searched for articles published through 16 December 2023. Eleven studies from eight countries were selected from 142 publications. The pooled prevalence of RLS was calculated using a random-effects model, with heterogeneity assessed by the Cochran Q and I 2 statistics. Meta-regression and sensitivity analyses explored sources of heterogeneity and the robustness of findings.
Results: Eleven studies, involving 20,255 blood donors, were included. The pooled prevalence of RLS among blood donors was 10.30% (95% confidence interval [CI]: 5.54%-16.30%), which was significantly higher than in the general adult population (3.0%, 95% CI: 1.4%-3.8%). Meta-regression identified the year of study and geographical region as significant sources of heterogeneity. From the five studies that used logistic regression analyses, female sex and older age stand out as associated factors. No publication bias was detected, and sensitivity analysis confirmed the robustness of results.
Conclusion: Our findings suggest a high burden of RLS among blood donors, underscoring the need for further research with standardized criteria, appropriate design and analytical methodologies to better understand the impact of RLS on individual donors and the global blood supply.
(© 2024 International Society of Blood Transfusion.)
Databáze: MEDLINE
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