Cutting Edge Microscopic Intraoperative Tissue Assessment for Guidance in Oncologic Surgery: A Systematic Review of the Role of Optical Coherence Tomography.

Autor:	Pavone M; Institute of Image-Guided Surgery, IHU Strasbourg, Strasbourg, France. matteopavone.21@gmail.com.; Research Institute against Digestive Cancer, IRCAD, Strasbourg, France. matteopavone.21@gmail.com.; Dipartimento di Scienze per la salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, UOC Ginecologia Oncologica, Rome, Italy. matteopavone.21@gmail.com.; ICube, Laboratory of Engineering, Computer Science and Imaging, Department of Robotics, Imaging, Teledetection and Healthcare Technologies, University of Strasbourg, CNRS, UMR 7357, Strasbourg, France. matteopavone.21@gmail.com., Innocenzi C; Dipartimento di Scienze per la salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, UOC Ginecologia Oncologica, Rome, Italy., Carles E; Department of Gynecologic Surgery, University Hospitals of Strasbourg, Strasbourg, France., Bizzarri N; Dipartimento di Scienze per la salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, UOC Ginecologia Oncologica, Rome, Italy., Moro F; Dipartimento di Scienze per la salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, UOC Ginecologia Oncologica, Rome, Italy., Ferrari FA; Department of Obstetrics and Gynecology, AOUI Verona, University of Verona, Verona, Italy., Nicolae A; Department of Pathology, University Hospitals of Strasbourg, Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg, France., Testa AC; Dipartimento di Scienze per la salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, UOC Ginecologia Oncologica, Rome, Italy.; Università Cattolica del Sacro Cuore, Rome, Italy., Fanfani F; Dipartimento di Scienze per la salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, UOC Ginecologia Oncologica, Rome, Italy.; Università Cattolica del Sacro Cuore, Rome, Italy., Fagotti A; Dipartimento di Scienze per la salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, UOC Ginecologia Oncologica, Rome, Italy.; Università Cattolica del Sacro Cuore, Rome, Italy., Marescaux J; Research Institute against Digestive Cancer, IRCAD, Strasbourg, France., Scambia G; Dipartimento di Scienze per la salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, UOC Ginecologia Oncologica, Rome, Italy.; Università Cattolica del Sacro Cuore, Rome, Italy., Akladios C; Department of Gynecologic Surgery, University Hospitals of Strasbourg, Strasbourg, France., Querleu D; Dipartimento di Scienze per la salute della Donna e del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli, IRCCS, UOC Ginecologia Oncologica, Rome, Italy., Lecointre L; Institute of Image-Guided Surgery, IHU Strasbourg, Strasbourg, France.; ICube, Laboratory of Engineering, Computer Science and Imaging, Department of Robotics, Imaging, Teledetection and Healthcare Technologies, University of Strasbourg, CNRS, UMR 7357, Strasbourg, France.; Department of Gynecologic Surgery, University Hospitals of Strasbourg, Strasbourg, France., Seeliger B; Institute of Image-Guided Surgery, IHU Strasbourg, Strasbourg, France.; Research Institute against Digestive Cancer, IRCAD, Strasbourg, France.; ICube, Laboratory of Engineering, Computer Science and Imaging, Department of Robotics, Imaging, Teledetection and Healthcare Technologies, University of Strasbourg, CNRS, UMR 7357, Strasbourg, France.; Department of Digestive and Endocrine Surgery, University Hospitals of Strasbourg, Strasbourg, France.
Jazyk:	angličtina
Zdroj:	Annals of surgical oncology [Ann Surg Oncol] 2024 Dec 08. Date of Electronic Publication: 2024 Dec 08.
DOI:	10.1245/s10434-024-16632-8
Abstrakt:	Introduction: There is a demand for intraoperative diagnostic support and image guidance in oncological surgery. Novel techniques can provide images similar to histopathological slides within a few minutes. Optical coherence tomography (OCT) and full-field OCT (FF-OCT) provide images with resolution greater than a hundred micrometers without the need for exogenous contrast agents or specimen staining. The aim of this systematic review was to assess the current clinical applications of OCT and dynamic cell imaging (DCI) in oncologic surgery, examining the translation challenges and proposing perspectives for improving future clinical applications. Materials and Methods: The study adhered to the PRISMA guidelines. PubMed, Google Scholar, and ClinicalTrials.gov were searched up to July 2024. Manuscripts reporting data on OCT and (D)-FF-OCT application in oncologic surgery were included in the qualitative analysis. Results: Thirty-one studies met the inclusion criteria. Most were from the fields of dermatologic (25.8%) and breast cancer (29%) surgery, followed by prostate and bladder (9.6%), ovarian (9.6%), head and neck (6.4%), gastrointestinal (6.4%), hepato-biliary (3.2%), and general surgery (9.6%). The majority of articles focused on FF-OCT and DCI (80.6%). Compared with the gold standard of final pathology, the OCT sensitivity ranged between 66.7 and 94%, the specificity between 64 and 100%, and the accuracy between 73 and 96%. Conclusions: The medical use of OCT has expanded from ophtalmology to other fields including gastroenterology and oncology and, with techniques such as FF-OCT and DCI, can enable rapid intraoperative diagnosis beyond classic histopathology. Competing Interests: Disclosure: Anna Fagotti. Grant/Research Support: AstraZeneca and MSD. Consultant for/Consulting fee: Fondazione Internazionale Menarini. Advisory Board: GlaxoSmithKline. Consultant for/Consulting fee: Oncoinvent A.S. Speakers Bureau/Honoraria: Covidien/Medtronic. Barbara Seeliger declares that she is the recipient of a grant from the French National Agency for Research (Agence Nationale de la Recherche (ANR), 86 rue Regnault, 75013 Paris, France) within the framework of the project AI-DIAL-Diagnostic Imaging of Adrenal Lesions (ANR-22-CE17-0019-01) and has a consultant agreement with Intuitive Surgical unrelated to the present study. (© 2024. Society of Surgical Oncology.)
Databáze:	MEDLINE
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