Locus coeruleus tau is linked to successive cortical tau accumulation.

Autor: Yi D; Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Seoul, Republic of Korea., Byun MS; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Seoul, Republic of Korea.; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Seoul, Republic of Korea., Jung JH; Department of Psychiatry, Chungbuk National University Hospital, Cheongju-si, Republic of Korea., Jung G; Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Seoul, Republic of Korea., Ahn H; Interdisciplinary Program of Cognitive Science, Seoul National University College of Humanities, Seoul, Seoul, Republic of Korea., Chang YY; Inje University Sanggye Paik Hospital, Seoul, Seoul, Republic of Korea., Keum M; Department of Neuropsychiatry, Soonchunhyang University Hospital, Bucheon-si, Gyeonggi-do, Republic of Korea., Lee JY; Department of Psychiatry, Seoul National University Boramae Medical Center, Seoul, Seoul, Republic of Korea., Lee YS; Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Seoul, Republic of Korea., Kim YK; Department of Nuclear Medicine, Seoul National University Boramae Medical Center, Seoul, Seoul, Republic of Korea., Kang KM; Department of Radiology, Seoul National University Hospital, Seoul, Seoul, Republic of Korea.; Department of Radiology, Seoul National University College of Medicine, Seoul, Seoul, Republic of Korea., Sohn CH; Department of Radiology, Seoul National University Hospital, Seoul, Seoul, Republic of Korea.; Department of Radiology, Seoul National University College of Medicine, Seoul, Seoul, Republic of Korea., Risacher SL; Indiana Alzheimer's Disease Research Center, Indianapolis, Indiana, USA.; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA., Saykin AJ; Indiana Alzheimer's Disease Research Center, Indianapolis, Indiana, USA.; Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Network Science Institute, Indiana University, Bloomington, Indiana, USA., Lee DY; Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Seoul, Republic of Korea.; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Seoul, Republic of Korea.; Department of Psychiatry, Seoul National University College of Medicine, Seoul, Seoul, Republic of Korea.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Dec 06. Date of Electronic Publication: 2024 Dec 06.
DOI: 10.1002/alz.14426
Abstrakt: Introduction: We investigated the hypothesis that tau burden in the locus coeruleus (LC) correlates with tau accumulation in cortical regions according to the Braak stages and examined whether the relationships differed according to cortical amyloid beta (Aβ) deposition.
Methods: One hundred and seventy well-characterized participants from an ongoing cohort were included. High-resolution T1, tau positron emission tomography (PET), and amyloid PET were obtained.
Results: LC tau burden was significantly linked to global tau in neocortical regions, as was tau in both early Braak stage (stage I/II) and later Braak stage areas. This relationship was significant only in Aβ-positive individuals. While LC tau did not directly impact memory, it was indirectly associated with delayed memory through mediation or moderation pathways.
Discussion: The findings from living human brains support the idea that LC tau closely relates to subsequent cortical tau accumulation, particularly among individuals with pathological Aβ accumulation, and identify LC tau burden as a promising indicator of cognitive trajectories of AD.
Highlights: Tau burden in the LC was significantly associated with cortical tau accumulation. Tau burden in SN or PPN showed no association with cortical tau accumulation. LC tau burden was serially associated with Braak stages. The tau-LC and cortical tau relationship was significant only in the Aβ-positive group. Cortical amyloid's impact on memory worsens with higher tau accumulation in the LC.
(© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
Externí odkaz: