Health-related fitness benefits following concurrent high-intensity interval training and resistance training in patients with type-1 diabetes or type-2 diabetes.

Autor: Scoubeau C; Cardio-Pulmonary Exercise Laboratory, Faculty of Motor Sciences, Université Libre de Bruxelles, Brussels, Belgium., Klass M; Research Unit in Biometry and Exercise Nutrition, Faculty of Motor Sciences, Université Libre de Bruxelles, Brussels, Belgium.; Laboratory of Applied Biology and Research Unit in Applied Neurophysiology, Faculty of Motor Sciences, ULB Neuroscience Institute, Université Libre de Bruxelles, Brussels, Belgium., Celie B; Cardio-Pulmonary Exercise Laboratory, Faculty of Motor Sciences, Université Libre de Bruxelles, Brussels, Belgium., Godefroid C; Department of Cardiology, Erasmus Hospital, Brussels, Belgium., Cnop M; ULB Center for Diabetes Research, Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium.; Division of Endocrinology, Erasmus Hospital, Brussels, Belgium., Faoro V; Cardio-Pulmonary Exercise Laboratory, Faculty of Motor Sciences, Université Libre de Bruxelles, Brussels, Belgium.
Jazyk: angličtina
Zdroj: Frontiers in physiology [Front Physiol] 2024 Nov 20; Vol. 15, pp. 1466148. Date of Electronic Publication: 2024 Nov 20 (Print Publication: 2024).
DOI: 10.3389/fphys.2024.1466148
Abstrakt: Introduction: Cardiorespiratory fitness (CRF), as assessed by VO 2 peak, along with metabolic and cardiovascular health indices, represents the strongest predictors of survival. However, it remains unclear whether concurrent high-intensity interval training (HIIT) and resistance training (RT) can similarly enhance these health markers in patients with type-1 diabetes (T1D) or type-2 diabetes (T2D) compared to healthy individuals.
Methods: Adults with uncomplicated T1D or T2D and healthy normoglycemic controls matched for sex and age (HC1 and HC2) performed 3 training sessions/week of concurrent HIIT and RT for 12 weeks. Pre- and post-intervention assessments included: lipids and glycemic profile, body composition (dual-energy x-ray absorptiometry) and a cyclo-ergometric cardio-pulmonary exercise test.
Results: Training improved VO 2 peak, the ventilatory threshold (VT1), maximal workload, ventilation and O 2 pulse, similarly in T1D in HC1 without changes in body composition or glycemic profile. In patients with T2D, training improved insulin sensitivity (HOMA-IR), lean mass, VE/VCO2 slope, VT1 and maximal O 2 pulse, workload and VO 2 peak with reduction in fat mass and visceral adipose tissue (VAT) (all, p < 0.05). However, improvements in VO 2 peak and O 2 pulse were lower than in healthy controls (respectively, T2D: +9%, HC2: +18% and T2D: +6%, HC2: +19%, p < 0.05).
Conclusions: Both patients with T1D and T2D benefit from combined HIIT and RT by improving CRF with specific adaptations influenced by the presence and type of diabetes. While identical magnitude of achievements were observed in T1D and HC1, T2D patients exhibited lower VO 2 peak and maximal O 2 pulse improvements but associated with notable additional health benefits regarding insulin sensitivity, body composition, visceral adipose tissue and ventilatory efficiency.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Scoubeau, Klass, Celie, Godefroid, Cnop and Faoro.)
Databáze: MEDLINE
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