The Multifaceted Role of the Polyphenol Curcumin: A Focus on Type 2 Diabetes Mellitus.

Autor:	Campagna R; Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy., Cecati M; Scientific Direction, Advanced Technology Center for Aging Research, IRCCS INRCA, Ancona, Italy., Vignini A; Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy.
Jazyk:	angličtina
Zdroj:	Current diabetes reviews [Curr Diabetes Rev] 2024 Nov 29. Date of Electronic Publication: 2024 Nov 29.
DOI:	10.2174/0115733998313402240726080637
Abstrakt:	Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by chronic hyperglycemia, which often co-exists with other metabolic impairments. This condition can damage various tissues and organs, resulting in the development of severe complications, both microvascular, such as retinopathy, nephropathy, and neuropathy, and macrovascular, responsible for an increased risk of cardiovascular diseases. Curcumin is the main bioactive molecule found in the rhizomes of turmeric. Many studies have reported curcumin to exhibit antioxidant, anti-inflammatory, anti-infectious, and anti-cancer properties; thus, there is an increasing interest in exploiting these properties in order to prevent the rise or the progression of T2DM, as well as its possible associated conditions. In this review, we have presented the current state-ofart regarding the clinical trials that have involved curcumin administration and analyzed the possible mechanisms by which curcumin might exert the beneficial effects observed in literature. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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