G1 and G2 variants of apolipoprotein L1 among Central African population in Trypanosoma brucei gambiense endemic rural area.

Autor:	Mupepe DM; Division of Cardiology, Department of Internal Medicine, University Hospital of Kinshasa, University of Kinshasa, The Democratic Republic of the Congo., Wameso MN; Service of Nephrology, Department of Internal Medicine, University Hospital of Kinshasa, University of Kinshasa, The Democratic Republic of the Congo., Situakibanza HN; Service of Infectious and Parasitic Pathologies, Department of Tropical Medicine, University Hospital of Kinshasa, University of Kinshasa, The Democratic Republic of the Congo., Ekulu PM; Pediatric Nephrology Unit, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, The Democratic Republic of the Congo., Makulo JRR; Service of Nephrology, Department of Internal Medicine, University Hospital of Kinshasa, University of Kinshasa, The Democratic Republic of the Congo., Kayembe JMN; Service of Pneumology, Department of Internal Medicine, University Hospital of Kinshasa, University of Kinshasa, The Democratic Republic of the Congo., Nkoy AB; Pediatric Nephrology Unit, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, The Democratic Republic of the Congo., Mvibudulu RZ; Service of Nephrology, Department of Internal Medicine, University Hospital of Kinshasa, University of Kinshasa, The Democratic Republic of the Congo., Van den Heuvel LP; Department of Development and Regeneration, KU Leuven, B 3000 Leuven, Belgium., Levtchenko EN; Department of Development and Regeneration, KU Leuven, B 3000 Leuven, Belgium., Karume KL; National Institute of Biomedical Research (INRB), Kinshasa, The Democratic Republic of the Congo., Bikoumou VA; Department of Radiology and medical imaging, University Hospital of Kinshasa, University of Kinshasa, The Democratic Republic of the Congo., Buila NB; Division of Cardiology, Department of Internal Medicine, University Hospital of Kinshasa, University of Kinshasa, The Democratic Republic of the Congo., Longo BM; Division of Cardiology, Department of Internal Medicine, University Hospital of Kinshasa, University of Kinshasa, The Democratic Republic of the Congo., Mumba DN; Service of Infectious and Parasitic Pathologies, Department of Tropical Medicine, University Hospital of Kinshasa, University of Kinshasa, The Democratic Republic of the Congo., M'Buyamba-Kabangu JR; Division of Cardiology, Department of Internal Medicine, University Hospital of Kinshasa, University of Kinshasa, The Democratic Republic of the Congo.
Jazyk:	angličtina
Zdroj:	Journal of infection in developing countries [J Infect Dev Ctries] 2024 Oct 31; Vol. 18 (10), pp. 1610-1616. Date of Electronic Publication: 2024 Oct 31.
DOI:	10.3855/jidc.19495
Abstrakt:	Introduction: Apolipoprotein L1 (APOL1) risk variants (G1, G2) are known to enhance the protective ability against human African trypanosomiasis (HAT), in addition to their role in kidney and cardiovascular disease. The effects of these variants on trypanosome infection could differ regionally owing to local adaptations of the host and pathogen. This study explored APOL1 risk variants distribution in HAT-infected and non-infected populations from a rural Trypanosoma brucei gambiense (T. b. gambiense) endemic area in Central Africa. Methodology: We conducted a cross-sectional study with 124 participants in Masimanimba, a HAT-endemic region in the Democratic Republic of the Congo (DRC). Student's and Pearson`s Chi-square test or Fisher's exact tests were used as appropriate. Statistical significance was set at p < 0.05, based on two-tailed test. Results: 71 participants (57%) were infected by Trypanosoma, 65 (52%) of whom were symptomatic and 6 (5%) asymptomatic. The overall frequency of risk alleles was 16.5% for G1 and 8.8% for G2. Neither variant was associated with the susceptibility to T. b. gambiense infection (for G1: 19.7% vs. 26.4 %; OR: 0.68 [95% CI: 0.29-1.62], p = 0.394; for G2: 11.3% vs. 13.2% 0.83 [0.27-2.58], p = 0.786). All of the G2 variants were found in symptomatic patients. Conclusions: APOL1 variants are common in populations living in T. b. gambiense endemic areas of the DRC. Neither variant was associated with susceptibility to T. b. gambiense. The G2 variant was the only one associated with symptomatic HAT. Competing Interests: No Conflict of Interest is declared (Copyright (c) 2024 Dominique M Mupepe, Marie-Noelle NL Wameso, Hippolyte N Situakibanza, Pépé M Ekulu, Jean Robert R Makulo, Jean Marie N Kayembe, Agathe B Nkoy, Raggue ZM Mvibudulu, Lambertus P Van den Heuvel, Elena N Levtchenko, Kevin L Karume, Victoire A Bikoumou, Nathan B Buila, Benjamin M Longo, Dieudonné N Mumba, Jean René M’Buyamba-Kabangu.)
Databáze:	MEDLINE
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