One-year follow-up evaluation of approved Subolesin anti-tick vaccine in Uganda.

Autor: Kasaija PD; National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization, Kampala P.O. Box 5704, Uganda., Kabi F; National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization, Kampala P.O. Box 5704, Uganda., Semakula J; National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization, Kampala P.O. Box 5704, Uganda., Kyakuwa I; National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization, Kampala P.O. Box 5704, Uganda., Contreras M; SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM), Ronda de Toledo 12, 13005 Ciudad Real, Spain., de la Fuente G; Sabiotec, Edificio incubadora de empresas UCLM, Camino de Moledores s/n, Ciudad Real 13071, Spain., Rutaisire J; National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization, Kampala P.O. Box 5704, Uganda., Mugerwa S; National Livestock Resources Research Institute (NaLIRRI), National Agricultural Research Organization, Kampala P.O. Box 5704, Uganda. Electronic address: mugerwaswidiq@gmail.com., Gortázar C; SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM), Ronda de Toledo 12, 13005 Ciudad Real, Spain., de la Fuente J; SaBio, Instituto de Investigación en Recursos Cinegéticos (IREC), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Castilla-La Mancha (UCLM)-Junta de Comunidades de Castilla-La Mancha (JCCM), Ronda de Toledo 12, 13005 Ciudad Real, Spain; Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078, USA. Electronic address: jose_delafuente@yahoo.com.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2024 Nov 28; Vol. 44, pp. 126562. Date of Electronic Publication: 2024 Nov 28.
DOI: 10.1016/j.vaccine.2024.126562
Abstrakt: After approval of the Subolesin-based anti-tick vaccine in Uganda, we completed a one-year follow-up evaluation study. The results showed significantly 2.1-5.0-fold higher anti-SUB IgG antibody titers in vaccinated cattle in Mbarara and Maruzi with vaccine effectiveness higher than 95 %. In Mbarara, total number of ticks were 0.8-fold lower in vaccinated cattle with a negative correlation tendency between anti-SUB antibody titers and tick counts. The CCHFV-seropositive cattle significantly decreased in 40 % in SUB-vaccinated animals with a significant positive correlation between CCHFV-seropositive cattle and the total number of ticks per animal and a negative correlation tendency between anti-SUB antibody titers and CCHFV-seropositive cattle. A boosting vaccine dose yearly after primary vaccination with three doses is sufficient to maintain protective antibody titers against ticks and tick-borne diseases affecting human and animal health. These results are relevant for implementation of anti-tick Subolesin-based vaccines in Uganda and other countries in Sub-Saharan Africa.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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