| Autor: |
Escobar Moreno JD; Semillero de Investigación de Medicina (SIMED), Basic and Translational Research Group (GIBAT), Faculty of Medicine, Universidad El Bosque, Bogotá 110121, Colombia., Fajardo Castiblanco JL; Semillero de Investigación de Medicina (SIMED), Basic and Translational Research Group (GIBAT), Faculty of Medicine, Universidad El Bosque, Bogotá 110121, Colombia., Riaño Rodriguez LC; Semillero de Investigación de Medicina (SIMED), Basic and Translational Research Group (GIBAT), Faculty of Medicine, Universidad El Bosque, Bogotá 110121, Colombia., Barrios Ospina PM; Semillero de Investigación de Medicina (SIMED), Basic and Translational Research Group (GIBAT), Faculty of Medicine, Universidad El Bosque, Bogotá 110121, Colombia., Zabala Bello CA; Laboratory of Animal Cytogenetics, Faculty of Veterinary Medicine and Animal Science, Universidad Nacional de Colombia, Bogotá 111321, Colombia., Muñoz Roa EN; PhD Program in Biological Sciences, Faculty of Science, Pontificia Universidad Javeriana, Bogotá 110231, Colombia., Rivera Escobar HM; Semillero de Investigación de Medicina (SIMED), Basic and Translational Research Group (GIBAT), Faculty of Medicine, Universidad El Bosque, Bogotá 110121, Colombia.; Department of Interdisciplinary Studies-DEI, Instituto de Educación a Distancia-IDEAD, BIOPESA Research Group, University of Tolima, Ibagué 730006, Colombia. |
| Abstrakt: |
Reactive oxygen species (ROS) are intermediates in oxidation-reduction reactions with the capacity to modify biomolecules and temporarily or permanently alter cell behaviour through signalling pathways under physiological and pathophysiological conditions where there is an imbalance between oxidative factors and the antioxidant response of the organism, a phenomenon known as oxidative stress. Evidence suggests that the differential modulation of ROS-mediated oxidative stress occurs in the pathogenesis and progression of melanoma, and that this imbalance in redox homeostasis appears to be functionally linked to microRNA (miRNA o miRs)-mediated non-mutational epigenetic reprogramming involving genes and transcription factors. The relationship between ROS-mediated stress control, tumour microenvironment, and miRNA expression in melanoma is not fully understood. The aim of this review is to analyse the involvement of miRNAs in the modulation of the signalling pathways involved in ROS-mediated oxidative stress in melanoma. It is hoped that these considerations will contribute to the understanding of the mechanisms associated with a potential epigenetic network regulation, where the modulation of oxidative stress is consolidated as a common factor in melanoma, and therefore, a potential footprint poorly documented. |
