Anxiety symptoms are differentially associated with facial expression processing in boys and girls.

Autor:	Doucet GE; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA.; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, USA., Kruse JA; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA., Keefe A; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA., Rice DL; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA., Coutant AT; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA., Pulliam H; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA., Smith OTV; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA., Calhoun VD; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA., Stephen JM; Mind Research Network, Albuquerque, NM, USA., Wang YP; Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA., White SF; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.; Nebraska Children and Families Foundation, Lincoln, NE, USA., Picci G; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA.; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, USA., Taylor BK; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA.; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, USA., Wilson TW; Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA.; Center for Pediatric Brain Health, Boys Town National Research Hospital, Boys Town, NE, USA.; Department of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE, USA.
Jazyk:	angličtina
Zdroj:	Social cognitive and affective neuroscience [Soc Cogn Affect Neurosci] 2024 Nov 26. Date of Electronic Publication: 2024 Nov 26.
DOI:	10.1093/scan/nsae085
Abstrakt:	Facial expressions convey important social information and can initiate behavioral change through the processing and understanding of emotions. However, while this ability is known to evolve throughout development, it remains unclear whether this ability differs between girls and boys or how other variables such as level of anxiety can modulate it. Furthermore, understanding the underlying neural mechanisms of facial expression processing and how they are linked by sex and anxiety during development is essential, as alterations in this processing have been associated with psychiatric disorders. Herein, 191 typically-developing youth (6-15 years-old) completed an implicit face processing task involving three facial expressions (angry, happy and neutral) during functional magnetic resonance imaging. We conducted linear models on the fMRI data to investigate the impact sex and anxiety on brain responses to emotional faces, accounting for age. Our findings indicated a significant anxiety-by-sex interaction in a posterior network covering bilateral visual and medial temporal cortices during the happy > neutral contrast. Specifically, girls with higher anxiety showed weaker activation while boys showed the opposite pattern. These findings suggest that the inter-subject variability reported in typically developing individuals in response to facial emotions may be related to many factors, including sex and anxiety level. (© The Author(s) 2024. Published by Oxford University Press.)
Databáze:	MEDLINE
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