Light-responsive antibacterial dissolving microneedles loaded with 5-aminolevulinic acid and silver nanoparticles for the treatment of acne.

Autor: Cao WY; School of Pharmacy, Bengbu Medical University, Bengbu, Anhui 233030, China., Zhao HQ; School of Pharmacy, Bengbu Medical University, Bengbu, Anhui 233030, China., Gu X; School of Pharmacy, Bengbu Medical University, Bengbu, Anhui 233030, China., Shao WJ; School of Pharmacy, Bengbu Medical University, Bengbu, Anhui 233030, China., Zheng LJ; School of Pharmacy, Bengbu Medical University, Bengbu, Anhui 233030, China., Zeng QY; School of Pharmacy, Bengbu Medical University, Bengbu, Anhui 233030, China., Wang ZK; School of Pharmacy, Bengbu Medical University, Bengbu, Anhui 233030, China; Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, Anhui 233030, China., Chen ML; CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China., Ma T; School of Pharmacy, Bengbu Medical University, Bengbu, Anhui 233030, China; Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, Anhui 233030, China., Li YY; School of Pharmacy, Bengbu Medical University, Bengbu, Anhui 233030, China; Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, Anhui 233030, China., Wang QQ; School of Pharmacy, Bengbu Medical University, Bengbu, Anhui 233030, China; Anhui Engineering Technology Research Center of Biochemical Pharmaceutical, Bengbu, Anhui 233030, China. Electronic address: qingqingwang@bbmc.edu.cn.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2024 Nov 21, pp. 124961. Date of Electronic Publication: 2024 Nov 21.
DOI: 10.1016/j.ijpharm.2024.124961
Abstrakt: Acne is a chronic inflammatory disease of pilosebaceous unit, which can be aggravated by hyperkeratosis of the pilosebaceous unit, excessive secretion of sebum and the proliferation of Propionibacterium acnes (P. acnes). Traditional drug treatment methods commonly exhibit drawbacks, including bacterial resistance and poor transdermal permeability, resulting in suboptimal efficacy and recurrent infections. Herein, we designed a dual drug-loaded microneedles patch to deliver ALA and silver nanoparticles for acne treatment. The comprehensive treatment of acne is achieved by utilizing the safe and efficient advantages of 5-aminolevulinic acid (ALA) photodynamic therapy (PDT), coupled with the superior antibacterial properties of silver nanoparticles. To enhance drug permeability, dissolving microneedles (DMNs) are employed for targeted and efficient drug delivery. In vitro and in vivo experiments demonstrated that DMNs loaded with both AgNPs and ALA-PDT (ALA/AgNPs@DMNs) have significant antibacterial activity, along with superior drug loading capacity and penetration. The application of ALA/AgNPs@DMNs in treating acne-affected rats alleviates excessive epidermal keratinization, effectively inhibits bacterial growth, and significantly improves acne symptoms. This suggests that the "dissolving microneedle" formulation holds promise for the treatment and management of acne.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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