Exploring the potential of a pH-sensitive hydrogel sponge: interpenetrating network of tragacanth and pectin for controlled delivery of levosulpiride.

Autor: Ashraf MU; Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan. muhammad.ashraf3@pharm.uol.edu.pk.; Faculty of Sciences, Equator University of Science and Technology, Masaka, Uganda. muhammad.ashraf3@pharm.uol.edu.pk., Iqbal MA; Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.; Faculty of Sciences, Equator University of Science and Technology, Masaka, Uganda., Barkat K; Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.; Faculty of Sciences, Equator University of Science and Technology, Masaka, Uganda., Anjum I; Department of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Mushtaq MN; Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.; Faculty of Sciences, Equator University of Science and Technology, Masaka, Uganda., Gul R; Department of Basic Medical Sciences, Shifa College of Pharmaceutical Sciences, Shifa Tameer-e-Millat University, Islamabad, Pakistan., Aamir M; Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.; Faculty of Sciences, Equator University of Science and Technology, Masaka, Uganda., Ibenmoussa S; Laboratory of Therapeutic and Organic Chemistry, Faculty of Pharmacy, University of Montpellier, 34000, Montpellier, France., Salamatullah AM; Department of Food Science & Nutrition, College of Food and Agricultural Sciences, King Saud University, 11 P.O. Box 2460, 11451, Riyadh, Saudi Arabia., Bourhia M; Department of Chemistry and Biochemistry, Faculty of Medicine and Pharmacy, Ibn Zohr University, 70000, Laayoune, Morocco. m.bourhia@uiz.ac.ma., Shazly GA; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi Arabia., Wondmie GF; Department of Biology, Bahir Dar University, P.O. Box 79, Bahir Dar, Ethiopia.
Jazyk: angličtina
Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Nov 23. Date of Electronic Publication: 2024 Nov 23.
DOI: 10.1007/s00210-024-03590-x
Abstrakt: The development of drug delivery systems that allow precise control over drug release pattern has fetched significant attention in the pharmaceutical field. This research work investigates the potential of a pH-sensitive interpenetrating network (IPN) composed of tragacanth and pectin as a carrier for the controlled release of levosulpiride. To enhance the solubility of poorly soluble drug levosulpiride, inclusion complexes were formed with beta cyclodextrin (βCD). The IPN was prepared by cross-linking tragacanth with pectin by adopting a green chemistry approach. The resulting cross-linked polymeric network was subjected to repetitive freeze-drying cycles for preparation of spongy mass. The physicochemical properties of the resultant product were thoroughly characterized using a range of analytical techniques, including Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermal analyses (DSC/TGA), and X-ray diffraction (XRD). The physical parameters like sol-gel fraction (%), drug loading (%), swelling behavior, electrolyte responsiveness, and in vitro drug release profile of the developed sponge were systematically evaluated under varying pH conditions. Results of FTIR demonstrated the formation of cross-linked network, ruling out drug-excipient interaction. SEM analysis unveiled porous and rough geometry. Thermal analyses proved the hydrogel network thermally stable whereas, PXRD demonstrated the overall amorphous nature of the hydrogel sponge. The outcomes of physical parameters demonstrated an incremental trend in gel fraction from 63 to 85% on raising the molar concentration of cross-linker from TP1 to TP3. However, increasing tragacanth content escalation in gel fraction from 75 to 79% was noticed. While gel fraction was augmented from 79 to 83% with increasing pectin contents. The maximum drug loading formulation TP3 was computed to be 89%. Hydrogel sponges also demonstrated electrolyte responsiveness. The release profile indicated a pH-responsive behavior, with sustained release up to 10 h observed in a buffer solution of pH 6.8 and 7.4. In an acidic medium, a minor amount of drug was released during 10 h dissolution. Drug release kinetics was observed to be in zero order. The findings of this study highlight the promising potential of the tragacanth/pectin hydrogel sponge as a pH-sensitive dais for the controlled delivery of levosulpiride, emphasizing its potential application in personalized drug therapy and the treatment of gastrointestinal disorders.
Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests. Human and animal rights and informed consent: Not applicable. Informed consent: Not applicable.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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