Antibacterial and Anti-Inflammatory Activity of Chitosan Film with Rhodomyrtus Tomentosa Leaf Extract Prepared Via 3D-Printing Method.

Autor: Vo-An Q; Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 100000, Vietnam., Nguyen CT; Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 100000, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 100000, Vietnam., Pham UT; Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 100000, Vietnam., Nguyen TA; Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 100000, Vietnam., Nguyen DT; Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 100000, Vietnam.; University Science and Technology Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 100000, Vietnam., Hoang DT; Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 100000, Vietnam., Le LT; Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 100000, Vietnam., Ngo QTC; Institute of Environmental Sciences, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, Ward 13, District 4, Ho Chi Minh City, 700000, Vietnam., Thai H; Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 100000, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, 100000, Vietnam.
Jazyk: angličtina
Zdroj: ChemistryOpen [ChemistryOpen] 2024 Nov 22, pp. e202400302. Date of Electronic Publication: 2024 Nov 22.
DOI: 10.1002/open.202400302
Abstrakt: The combination of natural polymers and plant extract attracted much attention thanks to its valuable biological activities. This study presents the preparation and characterization of chitosan (CS) film containing Rhodomyrtus tomentosa leaf extract. In which, the Rhodomyrtus tomentosa leaf extract (SLE) with polyphenol-rich fractions was extracted by an ultrasonic-assisted extraction method. The prepared chitosan/polyphenol-rich fractions film (CSPPF) was characterized using infrared (IR) spectroscopy, mechanical testing, scanning electron microscopy (SEM), and water absorption analysis. Antibacterial and anti-inflammatory activities of the CSPPF were assessed using the agar well diffusion method and nitric oxide (NO) inhibition assays, respectively. Besides, the release of the extract from the CSPPF as well as the drug release kinetics was also tested. The Rhodomyrtus tomentosa leaf extract enhanced the antibacterial efficacy against Escherichia coli and enhanced the anti-inflammatory activity as well as the swelling ability of the CSPPF. The CSPPF containing 1 wt.% of SLE can inhibit 77.70 % NO with an IC 50 value of 19.40 μg/mL.
(© 2024 The Authors. ChemistryOpen published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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