High pertussis circulation among infants, children and adolescents in Abidjan, Côte d'Ivoire.

Autor:	Soumahoro MK; Epidemiology Unit, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire., Noel G; Center of Translational Research, Institut Pasteur, Paris, France., Campana F; Institut Pasteur Medical Center, Paris, France., Koné CJ; Epidemiology Unit, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire., Rajabizadeh M; Institut Pasteur Medical Center, Paris, France., Sévédé D; Unité de Sérologie Bactérienne et Virale, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire., Ait Ahmed M; Clinical Research Coordination Center, Institut Pasteur, Paris, France., Kouassi KS; Molecular Biology Platform, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire., Kangah YL; Epidemiology Unit, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire., Deme-Dramé M; Pediatrics Ward, Hôpital Général de Port-Bouet, Abidjan, Côte d'Ivoire., N'Dri KM; Pediatrics Ward, Hôpital Général de Port-Bouet, Abidjan, Côte d'Ivoire., Ouattara-Abina MP; Pediatrics Ward for Children, Hôpital Général de Yopougon-Attié, Abidjan, Côte d'Ivoire., Tano N; Epidemiology Unit, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire., Sylla F; Pediatrics Ward, Centre de Santé Urbain à Base Communautaire d'Angré, Abidjan, Côte d'Ivoire., Cardenat M; Pediatrics Ward, Centre Hospitalier et Universitaire d'Angré, Abidjan, Côte d'Ivoire., Macina D; Global Medical, Sanofi, Lyon, France., Guiso N; Institut Pasteur, Paris, France., Taieb F; Institut Pasteur Medical Center, Paris, France.
Jazyk:	angličtina
Zdroj:	PloS one [PLoS One] 2024 Nov 20; Vol. 19 (11), pp. e0310965. Date of Electronic Publication: 2024 Nov 20 (Print Publication: 2024).
DOI:	10.1371/journal.pone.0310965
Abstrakt:	Background: Whooping cough due to Bordetella pertussis (BP) and/or B. parapertussis (BPP) is a highly contagious infection sometimes fatal for infants. Africa accounts for the largest share of cases and deaths worldwide. To evaluate pertussis circulation, we conducted a hospital-based prospective study (PS) including household contact-cases investigation (CCS) and a sero-epidemiological cross-sectional study (SECS). Methods: The PS, in which Bordetella diagnostics (qPCR) were performed, included infants aged ≤6 months presenting with ≥5 days of cough associated with one pertussis-like symptom. CCS was performed using qPCR and serology regardless of clinical signs. In the SECS, serology was performed in children aged 3-15 years with primary pertussis immunization. Results: Study took place in Abidjan between April 2019 and July 2021. In the PS, 187 infants with median age of 2.8 months were enrolled. A total of 42 (22.5%) were confirmed as positive, including 29 (15.5%), 4 (2.1%) and 9 (4.8%) of BP, BPP and BP/BPP coinfections respectively. Age <3 months, low BMI, apnea and inclusion period were identified as risk factors of infection. In the CCIS, 36 households were investigated, representing 158 people with median age of 21.4 years. BP and/or BPP infection was confirmed for 77/157 (49.0%). Twenty-nine households (81%) had at least one positive case. Sixty-seven (42.7%) contact cases were categorized as possibly contaminated, mainly siblings older than five years (25.4%). Twenty-seven contact cases were considered as possible contaminators, primarily mothers (26%). In the SECS, 444 people were enrolled. Two hundred and thirty-eight (53.6%) and nine (2.0%) children had received one and two boosters, respectively. A positive serology was observed in 96 (21.7%) of children and adolescents. Conclusion: Our study highlighted high circulation of pertussis. Barriers to accessing boosters recommended by WHO need to be overcome. Laboratory capacities are key at individual level and to build an effective surveillance system. Competing Interests: Denis Macina is an employee of Sanofi and declares holding shares of the Sanofi group as part of his compensation. There are no patents, products in development or marketed products associated with this research to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials. (Copyright: © 2024 Soumahoro et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze:	MEDLINE
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