A Gastrointestinal Manifestation of Primary Cutaneous Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma: A Case Report.

Autor:	Edeson ME; Internal Medicine, Hackensack Meridian Health, Hackensack Meridian School of Medicine, Nutley, USA., Burg E; Internal Medicine, Hackensack Meridian Health, Hackensack Meridian School of Medicine, Nutley, USA., Sharbin GK; Internal Medicine, Hackensack Meridian Health, Hackensack Meridian School of Medicine, Nutley, USA., Hosseini DK; Internal Medicine, Hackensack Meridian Health, Hackensack University Medical Center, Hackensack, USA., Churrango J; Gastroenterology, Hackensack Meridian Health, Palisades Medical Center, North Bergen, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Oct 20; Vol. 16 (10), pp. e71953. Date of Electronic Publication: 2024 Oct 20 (Print Publication: 2024).
DOI:	10.7759/cureus.71953
Abstrakt:	Cutaneous T-cell lymphomas (CTCL) are the most frequently encountered form of primary cutaneous lymphoma (PCL). Although this group of diseases primarily affects the skin, extracutaneous manifestations are reported. Primary cutaneous aggressive epidermotropic cytotoxic T-cell lymphoma (pcAECTCL) is a rare form of CTCL that usually presents with an aggressive course and poor prognosis. Given the scarcity of cases, the disease is poorly understood. There have been reports of cases of extracutaneous manifestations of the disease, with more aggressive courses associated with an increased propensity for systemic spread. The most common extracutaneous manifestations of pcAECTCL include those affecting the lungs, central nervous system, testis, and oral mucosa, which can cause progressive dysphagia. We describe a patient with a chronic relapsing/remitting rash diagnosed as pcAECTCL. A positron emission tomography (PET) scan revealed diffuse uptake within the gastric region. Initial esophagogastroduodenoscopy (EGD) showed multiple ulcerations and erosions in the stomach with concern for extracutaneous spread of the patient's pcAECTCL. However, no definitive histopathological or flow immunophenotypic evidence of metastasis was found on the initial or subsequent repeat EGD. Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Edeson et al.)
Databáze:	MEDLINE
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