| Autor: |
Abdi EA, Kamitomo VJ, McPherson TA, Konrad MW, Inoue M, Tan YH |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and investigative medicine. Medecine clinique et experimentale [Clin Invest Med] 1986; Vol. 9 (1), pp. 33-40. |
| Abstrakt: |
Ten patients with advanced cancer were treated with weekly intravenous escalating doses of human beta-interferon (HuIFN beta) 4 days each week. The starting dose of HuIFN beta was 3.0 X 10(6) units/m2 and the dose was doubled each week until dose-limiting toxicity was observed. Subjective toxicity included mild fevers and chills, malaise and flu-like symptoms. The lowest dose which caused suppression of the platelet and/or white cell count was 64 X 10(6) units daily, and the maximum dose given was 320 X 10(6) units daily. Both subjective and objective toxicity were not dose-related, easily managed and reversible. Serum interferon levels and the duration of measurable interferon activity on natural killer cells was in general dose-dependent. Two patients had an objective partial response, and two others showed stable disease while receiving HuIFN beta. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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