Imbalance of Myoinositol and D-Chiro-Inositol in Saliva of Children With Type-1 Diabetes Mellitus: A Cross-Sectional Study.

Autor: Lima PHM; Postgraduate Program in Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceara, Fortaleza, Ceara, Brazil., Alves Cabral KSDS; Postgraduate Program in Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceara, Fortaleza, Ceara, Brazil., Costa E Forti A; Health Department of the State of Ceara, Integrated Center of Diabetes and Hypertension, Fortaleza, Ceara, Brazil., Nascimento NRFD; Superior Institute of Biomedical Science, State University of Ceara, Fortaleza, Ceara, Brazil., Santos CF; Superior Institute of Biomedical Science, State University of Ceara, Fortaleza, Ceara, Brazil., Lima AAM; National Institute of Biomedicine of the Brazilian SemiArid, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil., Magalhães LMVC; National Institute of Biomedicine of the Brazilian SemiArid, Faculty of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil., Martins RS; Postgraduate Program in Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceara, Fortaleza, Ceara, Brazil., Lima V; Postgraduate Program in Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceara, Fortaleza, Ceara, Brazil., Fonteles MC; Superior Institute of Biomedical Science, State University of Ceara, Fortaleza, Ceara, Brazil., Fonteles CSR; Department of Pediatric Dentistry, School of Dentistry, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Jazyk: angličtina
Zdroj: Clinical endocrinology [Clin Endocrinol (Oxf)] 2024 Nov 18. Date of Electronic Publication: 2024 Nov 18.
DOI: 10.1111/cen.15164
Abstrakt: Objective: Earlier work suggests Myoinositol (MI) and D-chiro- inositol (DCI) imbalance in urine and plasma of diabetic patients, and their potential for monitoring insulin resistance. This study aimed to assess levels of Myoinositol (MI) and D-chiro- inositol (DCI) in saliva of children with type 1 diabetes mellitus (DM-1) and controls, to verify if concentrations of MI and DCI are similarly altered in saliva, exploring their potential for monitoring DM-1.
Design, Patients and Measurements: This cross-sectional clinical study enroled 45 patients (DM-1, n = 25; Controls, n = 20). Children aged 3-12 years with fasting blood glucose levels > 126 mg/dL, and HbA1c levels > 7%. Saliva was collected, and salivary measurements included pH, flow rates and concentrations of MI, DCI and glucose, employing high-performance liquid chromatography. Periodontal health was assessed using bleeding and plaque indices.
Results: Children with DM-1 showed elevated MI (p = 0.001), reduced DCI (p = 0.001), and increased MI-DCI ratio (p = 0.001). The MI-DCI ratio was elevated by 16-fold among diabetic children. Plaque (p = 0.003) and gingival bleeding (p = 0.001) were higher in DM-1 than controls. The MI increased the odds of an outcome of DM-1 by 174%, while DCI reduced the odds by 63%, highlighting their strong and opposing effects on DM-1.
Conclusions: Children with DM-1 express higher MI and lower DCI levels, while non-diabetic children show an inversion of these concentrations. Inositol imbalance in saliva of diabetic children resembles previous results in urine, and represents a possible venue for monitoring this disease, paving the way for future investigations into salivary inositols.
(© 2024 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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