Antioxidant, anticancer, and anti-inflammatory potential of Moringa seed and Moringa seed oil: A comprehensive approach.

Autor: Shahbaz M; Department of Food Science and Technology Muhammad Nawaz Shareef University of Agriculture Multan Multan Pakistan., Naeem H; Department of Food Science and Technology Muhammad Nawaz Shareef University of Agriculture Multan Multan Pakistan.; Food Technology Section, Post-Harvest Research Centre Ayub Agricultural Research Institute Faisalabad Pakistan., Batool M; Department of Food Science and Technology Muhammad Nawaz Shareef University of Agriculture Multan Multan Pakistan., Imran M; Department of Food Science and Technology University of Narowal Narowal Pakistan., Hussain M; Department of Food Sciences Government College University Faisalabad Faisalabad Pakistan., Mujtaba A; Department of Food Science and Technology, Faculty of Engineering and Technology Hamdard University Islamabad Campus Islamabad Pakistan., Alsagaby SA; Department of Medical Laboratory Sciences, College of Applied Medical Sciences Majmaah University AL-Majmaah Saudi Arabia., Al Abdulmonem W; Department of Pathology, College of Medicine Qassim University Buraidah Saudi Arabia., El-Ghorab AH; Department of Chemistry, College of Science Jouf University Sakaka Saudi Arabia., Ghoneim MM; Department of Pharmacy Practice, College of Pharmacy AlMaarefa University Ad Diriyah Saudi Arabia.; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy Al-Azhar University Cairo Egypt., Shaker ME; Department of Pharmacology, College of Pharmacy Jouf University Sakaka Saudi Arabia.; Department of Pharmacology & Toxicology, Faculty of Pharmacy Mansoura University Mansoura Egypt., Abdelgawad MA; Department of Pharmaceutical Chemistry, College of Pharmacy Jouf University Sakaka Saudi Arabia., Al Jbawi E; Syrian Arab Republic Ministry of Agriculture and Agrarian Reform Damascus Syria.
Jazyk: angličtina
Zdroj: Food science & nutrition [Food Sci Nutr] 2024 Jul 09; Vol. 12 (9), pp. 6157-6173. Date of Electronic Publication: 2024 Jul 09 (Print Publication: 2024).
DOI: 10.1002/fsn3.4312
Abstrakt: Moringa oleifera, a widely recognized plant more commonly known as moringa, has obtained significant research interest in recent years due to its prospective physiological advantages, including its claimed ability to counteract carcinogenesis. The moringa plant has been found to possess bioactive components that exhibit promising anticancer activities against different human cancers, such as breast cancer, prostate cancer, pancreatic cancer, etc. The cytotoxic properties of moringa seed extracts on cancerous cells have also been provided in this paper along with other notable health benefits. The extracts derived from moringa seeds inhibit cancer proliferation and promote cancer cell apoptosis through multiple signaling pathways. They also stimulated intracellular reactive oxygen species (ROS) production and subsequently induced caspase-3 activity. The impact of moringin and avenanthramide 2f on the stimulation of caspases 2, 4, 8, and 9 results in reduction in the proliferation of cancer cells. The results reported by research studies hold significant implications for identifying and targeting specific molecular entities that could serve as potential therapeutic targets in search of effective cancer treatments. Furthermore, the flavonoids in moringa seed can remove mitochondrial reactive oxygen species, protecting beta cells and bringing hyperglycemia under control. M. oleifera seed oil can reduce the risk of cardiovascular diseases via reduced malondialdehyde (MDA) formation and modulation of cardiac superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity. This article provides a comprehensive summary of the noteworthy discoveries derived from a rigorous investigation that explored into the impact of moringa seeds on the prevention/reduction of various cancers and other complex diseases.
Competing Interests: The authors declare no conflict of interest.
(© 2024 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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