Cytotoxic monoterpenoid indole alkaloids from Tabernaemontana bovina.

Autor: Tan BY; School of Pharmaceutical Sciences, College of Modern Biomedical Industry, Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, People's Republic of China., Lin H; School of Pharmaceutical Sciences, College of Modern Biomedical Industry, Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, People's Republic of China., Zhang HG; College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Traditional Chinese Medicine, Kunming, 650500, People's Republic of China; School of Hospitality and Tourism Management, College of Hospitality, University of South Carolina, Columbia, 29208, United States., Zhao JZ; School of Pharmaceutical Sciences, College of Modern Biomedical Industry, Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, People's Republic of China., Deng SY; School of Pharmaceutical Sciences, College of Modern Biomedical Industry, Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, People's Republic of China., Guo RR; School of Pharmaceutical Sciences, College of Modern Biomedical Industry, Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, People's Republic of China., Wei X; School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, People's Republic of China., Zhang LC; School of Pharmaceutical Sciences, College of Modern Biomedical Industry, Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, People's Republic of China. Electronic address: zhlch_2010@163.com., Zhang RP; College of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Traditional Chinese Medicine, Kunming, 650500, People's Republic of China. Electronic address: zhrpkm@163.com., Yu HF; School of Pharmaceutical Sciences, College of Modern Biomedical Industry, Department of Zoology & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, 650500, People's Republic of China. Electronic address: yuhaofei@kmmu.edu.cn.
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2024 Nov 15; Vol. 230, pp. 114336. Date of Electronic Publication: 2024 Nov 15.
DOI: 10.1016/j.phytochem.2024.114336
Abstrakt: Chemical investigation of the native medicinal plant Tabernaemontana bovina led to the isolation of five previously unreported monoterpenoid indole alkaloids tabernovinaines A-E (1-5) together with twenty-seven known analogs (6-32), including a bisindole alkaloid 1 with the (E)-4-aminobut-3-en-2-one fragment, as well as a unique cage skeleton 2 containing 6/5/8/6/6 ring system. The chemical structures of these unreported compounds were elucidated using mass spectrometry, NMR spectroscopy, circular dichroism, density functional theory calculations, and derivatizations. The activity evaluation shows that the bisindole alkaloid 1 revealed a potential cytotoxic effect by inducing HepG2 cell apoptosis and damaging clonal sphere expansion.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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