Antimicrobial Resistance and Zoonotic Potential of Nontyphoidal Salmonella From Household Dogs.

Autor: Kenney SM; Department of Animal Science, The Pennsylvania State University, University Park, Pennsylvania, USA.; Molecular, Cellular, and Integrative Biosciences Graduate Program, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.; One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA., M'ikanatha NM; Department of Food Science, The Pennsylvania State University, University Park, Pennsylvania, USA.; Pennsylvania Department of Health, Harrisburg, Pennsylvania, USA., Ganda E; Department of Animal Science, The Pennsylvania State University, University Park, Pennsylvania, USA.; One Health Microbiome Center, Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Jazyk: angličtina
Zdroj: Zoonoses and public health [Zoonoses Public Health] 2024 Nov 15. Date of Electronic Publication: 2024 Nov 15.
DOI: 10.1111/zph.13174
Abstrakt: Background: Companion animals, like household dogs, are an overlooked transmission point for zoonotic pathogens such as nontyphoidal Salmonella (NTS). Given the proximity of dogs to humans and the use of critically important antibiotics in companion animal medicine, household dogs represent a risk for the spread of antimicrobial-resistant (AMR) Salmonella.
Methods and Results: To this end, we aimed to leverage existing biosurveillance infrastructure to investigate AMR and the zoonotic potential of NTS isolated from dogs and humans. We identified all NTS strains isolated from domestic dogs via the Veterinary Laboratory Investigation and Response Network between May 2017 and March 2023 (N = 87), and spatiotemporally matched strains isolated from humans in the NCBI Pathogen Isolate Browser (N = 77). These 164 strains, collected from 17 states in the United States, formed the basis of our analysis. Strains isolated from dogs comprised diverse serovars, with most being clinically relevant to human health. All strains possessed AMR determinants for drug classes deemed critically or highly important by the World Health Organization. We identified sixteen NTS isolates from humans closely related to ≥1 of six dog-associated strains.
Conclusions: Collectively, our data emphasize the importance of antimicrobial stewardship and sustained biosurveillance beyond human- and agriculture-associated veterinary medicine, using a One-Health framework that accounts for all transmission points including companion animals.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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