Organelle-level toxicity of nanometals relevant to titanium implants. Original research and comprehensive literature overview.

Autor: Zaimoglu M; Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey. Electronic address: muratzaim2024@gmail.com., Secinti KD; Department of Neurosurgery, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey., Altinoz MA; Department of Medical Biochemistry, Acibadem University, Altunizade, Istanbul, Turkey., Bozkurt M; Department of Neurosurgery, Istanbul Arel University, Istanbul, Turkey; Department of Neurosurgery, Memorial Bahcelievler Hospital, Memorial Health Group, Istanbul, Turkey., Eroglu U; Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey., Ozpiskin O; Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey., Mammadkhanli O; Department of Neurosurgery, Faculty of Medicine, Trakya University, Edirne, Turkey., Bayatli E; Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey., Caglar YS; Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey., Attar A; Department of Neurosurgery, Faculty of Medicine, Ankara University, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Tissue & cell [Tissue Cell] 2024 Dec; Vol. 91, pp. 102612. Date of Electronic Publication: 2024 Nov 10.
DOI: 10.1016/j.tice.2024.102612
Abstrakt: Objective: This study analyzed organelle toxicities of nanometals applied as free formulations or titanium rod-coating materials in rats.
Methods: All materials were injected intraperitoneally, including the physiological saline applied to the control group. The first experimental group was implanted with nanosilver-coated titanium rods, and the second, third, and fourth groups received free nanosilver at rising levels. The fifth group was implanted with nanosilver, nanocopper, and nanozinc-coated titanium rods, and the sixth group received the same nanometals as free formulations. Light and electron microscopy and ICP-Mass Spectrometry were utilized to determine the neural, hepatic, and renal toxicities and tissue metal levels.
Results: In brains, neuropil, myelin, and cellular damages occurred, especially in groups receiving high-dose nanosilver or nanometal combinations. Histiocyte accumulation and dark mitochondria within hepatocytes were discernible in the liver. Kidneys were the organs that were most severely affected by nanometal toxicity. The nephrotoxicity was apparent with the perturbations of the membrane infoldings and mitochondrial damage in the proximal and distal convoluted epithelia. Large angular peroxisomes developed inside the mesangial cells, and Golgi bodies increased in epithelial cells. Systemic metal levels increased on the thirtieth and prominently dropped on the sixtieth day.
Conclusion: These results provide insights into the extent of injury and organelle targets of nanometals and will guide optimizing the nanomaterials and implants used in the surgical practice.
Competing Interests: Conflict of Interest None to declare.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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