Social isolation intensifies adgrl3.1-related externalizing and internalizing behaviors in zebrafish.

Autor: Fontana BD; Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Brazil. Electronic address: fontana.bd@gmail.com., Alnassar N; Barts Cancer Institute, Queen Mary University of London, London, UK., Norton WHJ; Department of Genetics, Genomics and Cancer Science, University of Leicester, Leicester LE1 7RH, UK., Parker MO; School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK; Surrey Sleep Research Centre, University of Surrey, Guildford, UK. Electronic address: matthew.parker@surrey.ac.uk.
Jazyk: angličtina
Zdroj: Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2024 Nov 12; Vol. 136, pp. 111193. Date of Electronic Publication: 2024 Nov 12.
DOI: 10.1016/j.pnpbp.2024.111193
Abstrakt: Externalizing disorders (EDs) are characterized by outward-directed behaviors such as aggression and hyperactivity. They are influenced by gene-environment interactions, yet our understanding of the genetic predispositions and environmental contexts that give rise to them is incomplete. Additionally, people with EDs often exhibit comorbid internalizing symptoms, which can complicate the clinical presentation and treatment strategies. Following on from our previous studies, we examined genes x environment interaction as a risk factor for EDs by looking at internalizing and externalizing behaviors after social isolation. Specifically, we subjected adgrl3.1 knockout zebrafish - characterized by hyperactivity and impulsivity - to a 2-week social isolation protocol. We subsequently assessed the impact on anxiety-like behavior, abnormal repetitive behaviors, working memory, and social interactions. Genotype-specific additive effects emerged, with socially isolated adgrl3.1 knockout fish exhibiting intensified comorbid phenotypes, including increased anxiety, abnormal repetitive behaviors, reduced working memory, and altered shoaling, when compared to WT fish. The findings demonstrate that genetic predispositions interact with environmental stressors, such as social isolation, to exacerbate both externalizing and internalizing symptoms. This underlines the necessity for comprehensive diagnostic and intervention strategies.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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