Clerodendrum trichotomum Extract Attenuates UV-B-Induced Skin Impairment in Hairless Mice by Inhibiting MAPK Signaling.

Autor: Kim KM; KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.; Department of Korean Convergence Medical Science, Korea National University of Science and Technology (UST), Daejeon, Republic of Korea., Im AR; Research Laboratories, Ildong Pharmaceutical Co. Ltd, Gyeononggi-do, Republic of Korea., Shim KS; KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea., Lee AY; KM Data Division, Korea Institute of Oriental Medicine, Yuseong-daero1672, Daejeon, Republic of Korea., Kim T; KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea., Choi SA; Department of Bioinformatics and Biosystems, Seongnam Campus of Korea Polytechnics, Gyeonggi-do, Republic of Korea., Nam KW; Soonchunhyang University Industry-Academic Cooperation Foundation, Asan, Republic of Korea., Lee S; Department of Plant Science and Technology, Chung-Ang University, Anseong, Republic of Korea., Hyun JW; Department of Biochemistry, College of Medicine, and Jeju Research Center for Natural Medicine, Jeju National University, Jeju City, Republic of Korea., Chae S; KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.; Department of Korean Convergence Medical Science, Korea National University of Science and Technology (UST), Daejeon, Republic of Korea.
Jazyk: angličtina
Zdroj: Photodermatology, photoimmunology & photomedicine [Photodermatol Photoimmunol Photomed] 2024 Nov; Vol. 40 (6), pp. e13011.
DOI: 10.1111/phpp.13011
Abstrakt: Background: Exposure to solar ultraviolet-B (UV-B) radiation significantly accelerates skin aging by inducing the expression of matrix metalloproteinases (MMPs) such as MMP-1, leading to alterations in the extracellular matrix and consequent photoaging. Some plant components, renowned for their UV-absorbing and antioxidative properties, show potential for mitigating photoaging by reducing UV-B-induced MMP levels. In this context, we explored the inhibitory effects of Clerodendrum trichotomum extract (CTE) on UV-B-induced skin damage.
Methods: The mechanism of CTE was predicted using network pharmacology approach. Also, antiaging efficacy was evaluated by mouse model and cellular system using human epidermal keratinocytes (HEKa), including its modulation of mitogen-activated protein kinase (MAPK) signaling pathways.
Results: CTE effectively counters UV-B-induced skin damage, as evidenced by the suppression of MMP-9 and MMP-1 expression in mice. We found that each fraction and chemical constituents of CTE suppressed UV-B-induced MMP-1 secretion in HEKa cells.
Conclusion: CTE inhibits UV-B-induced skin aging by partially suppressing MMP-1 and MMP-9 secretion via the modulation of MAPK signaling pathways.
(© 2024 The Author(s). Photodermatology, Photoimmunology & Photomedicine published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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