Chemical profiles and antibacterial actions of Zanthoxylum acanthopodium DC. Essential oil growing in Indonesia.

Autor: Septama AW; Research Center for Pharmaceutical Ingredient and Traditional Medicine, National Research and Innovation Agency (BRIN), KST Soekarno, Cibinong, Jawa Barat 16911, Indonesia. Electronic address: abdi001@brin.go.id., Rahmi EP; Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta, Jl. Rs. Fatmawati, Pondok Labu, Jakarta Selatan 12450, Indonesia. Electronic address: eldizapr@upnvj.ac.id., Tasfiyati AN; Research Center for Chemistry, National Research and Innovation Agency (BRIN), KST BJ Habibie, Serpong, Tangerang Selatan, Banten 15314. Indonesia; Department of Biochemical Engineering, University College London, Gower St, London WC1E 6AE, United Kingdom., Khairunnisa NA; Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia., Nasution HR; Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia., Nirmal N; Institute of Nutrition, Mahidol University, 999 Phutthamonthon 4 Road, Salaya, Nakhon Pathom 73170, Thailand., Banjarnahor SDS; Research Center for Pharmaceutical Ingredient and Traditional Medicine, National Research and Innovation Agency (BRIN), KST Soekarno, Cibinong, Jawa Barat 16911, Indonesia., Nurhadi; Research Center for Pharmaceutical Ingredient and Traditional Medicine, National Research and Innovation Agency (BRIN), KST Soekarno, Cibinong, Jawa Barat 16911, Indonesia., Priyatmojo D; Research Center for Pharmaceutical Ingredient and Traditional Medicine, National Research and Innovation Agency (BRIN), KST Soekarno, Cibinong, Jawa Barat 16911, Indonesia.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2024 Nov 12; Vol. 180, pp. 106300. Date of Electronic Publication: 2024 Nov 12.
DOI: 10.1016/j.fitote.2024.106300
Abstrakt: Foodborne illness caused by pathogens has been a major health problem. Antibacterial resistance renders therapeutic options for treating the condition more limited, hence there is a growing interest in finding novel antibacterial alternatives. Zanthoxylum acanthopodium (Rutaceae) essential oil (ZAEO) has a substantial potential to suppress the growth of bacterial infections. This study was conducted to evaluate antibacterial activity of ZAEO against four species of foodborne pathogens that cause potential infections. The checkerboard assay was used to identify synergistic effect of ZAEO and tetracycline, while bacteriolysis test was applied to evaluate the ability of ZAEO releasing material genetics of bacteria, inhibiting biofilm formation, and suppressing efflux pump. The oils of Z. acanthopodium was evaluated and showed that the highest constituents were limonene and geranyl acetate at 47.13 % and 23.84 %, respectively. These oils have the strongest ability to inhibit Escherichia coli compared to other pathogens with MIC value of 62.5 μg/mL. ZAEO and tetracycline also presented a synergistic effect against E. coli with FICI value of 0.37. Moreover, this combination of ZAEO and antibiotic shown as potential antibacterial agent by several mechanisms such as, decreasing biofilm formation, releasing ions, rupturing membrane cells, and suppressing the efflux pump of E. coli. It can be concluded that ZAEO and tetracycline presented a promising antibacterial activity, which can be explored further to develops antibacterial agents against foodborne pathogens.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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