Motor learning promotes regionally-specific spindle-slow wave coupled cerebral memory reactivation.

Autor: Baena D; Sleep Unit, University of Ottawa Institute of Mental Health Research at The Royal, Ottawa, ON, Canada.; School of Psychology, University of Ottawa, Ottawa, ON, Canada., Gabitov E; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Ray LB; School of Psychology, University of Ottawa, Ottawa, ON, Canada., Doyon J; McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, QC, Canada., Fogel SM; Sleep Unit, University of Ottawa Institute of Mental Health Research at The Royal, Ottawa, ON, Canada. sfogel@uottawa.ca.; School of Psychology, University of Ottawa, Ottawa, ON, Canada. sfogel@uottawa.ca.; University of Ottawa Brain & Mind Research Institute, Ottawa, ON, Canada. sfogel@uottawa.ca.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2024 Nov 12; Vol. 7 (1), pp. 1492. Date of Electronic Publication: 2024 Nov 12.
DOI: 10.1038/s42003-024-07197-z
Abstrakt: Sleep is essential for the optimal consolidation of newly acquired memories. This study examines the neurophysiological processes underlying memory consolidation during sleep, via reactivation. Here, we investigated the impact of slow wave - spindle (SW-SP) coupling on regionally-task-specific brain reactivations following motor sequence learning. Utilizing simultaneous EEG-fMRI during sleep, our findings revealed that memory reactivation occured time-locked to coupled SW-SP complexes, and specifically in areas critical for motor sequence learning. Notably, these reactivations were confined to the hemisphere actively involved in learning the task. This regional specificity highlights a precise and targeted neural mechanism, underscoring the crucial role of SW-SP coupling. In addition, we observed double-dissociation whereby primary sensory areas were recruited time-locked to uncoupled spindles; suggesting a role for uncoupled spindles in sleep maintenance. These findings advance our understanding the functional significance of SW-SP coupling for enhancing memory in a regionally-specific manner, that is functionally dissociable from uncoupled spindles.
Competing Interests: Competing interests The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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