Pentamethine cyanine dyes with alkynyl group as perspective structure for conjugation with targeting moiety.

Autor: Uspenskaia AA; Lomonosov Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation. Electronic address: uspenskaya.n@gmail.com., Doroshenko IA; Lomonosov Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation., Popovicheva KA; Lomonosov Moscow State University, Fundamental Physical and Chemical Engineering Dept., Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation., Shmychkov NV; Lomonosov Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation., Pryakhina EV; National Research University Higher School of Economics, Biology and Biotechnology Dept., Profsoyuznaya St., 33/4, Moscow 117418, Russian Federation., Shafikov RR; Lomonosov Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, Moscow 117997, Russian Federation., Skvortsov DA; Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, Moscow 117997, Russian Federation., Beklemishev MK; Lomonosov Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation., Zaborova OV; Lomonosov Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation., Podrugina TA; Lomonosov Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation., Machulkin AE; Lomonosov Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation; Department for Biochemistry, People's Friendship University of Russia Named after Patrice Lumumba (RUDN University), 117198, Moscow, Russia., Beloglazkina EK; Lomonosov Moscow State University, Chemistry Dept., Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation.
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Nov 10; Vol. 115, pp. 130025. Date of Electronic Publication: 2024 Nov 10.
DOI: 10.1016/j.bmcl.2024.130025
Abstrakt: We report a modified carbocyanine-based asymmetric fluorescent dye, suitable for the azide-alkyne cycloaddition reaction, that possesses promising photochemical properties (Φ fl  = 0,49). As an example of usage of the new fluorophore, it was conjugated to a ligand targeting prostate-specific membrane antigen (PSMA), one of the widely utilized prostate cancer markers.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Anastasiia A. Uspenskaia reports financial support was provided by Russian Science Foundation. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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