Reproductive, obstetrical and oncological outcomes of fertility-sparing treatment for cervical cancer according to the FIGO 2018 staging system: A systematic review.

Autor: Taliento C; Department of Medical Sciences, Institute of Obstetrics and Gynecology, University of Ferrara, Ferrara, Italy; Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Scutiero G; Department of Medical Sciences, Institute of Obstetrics and Gynecology, University of Ferrara, Ferrara, Italy., Battello G; Department of Medicine (DMED), University of Udine, Udine, Italy., Sala A; Department of Medicine (DMED), University of Udine, Udine, Italy., Pellecchia G; Department of Medicine (DMED), University of Udine, Udine, Italy., Trozzi R; Dipartimento per la salute della Donna e del Bambino e della Salute Pubblica, UOC Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy., Arcieri M; Department of Maternal and Child Health, Obstetrics and Gynecology Clinic, Ospedale Santa Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy. Electronic address: martina.arcieri@asufc.sanita.fvg.it., Pavone M; Università Cattolica del Sacro Cuore, Roma, Italy; IHU Strasbourg, Institute of Image-Guided Surgery, Strasbourg, France., Bizzarri N; Dipartimento per la salute della Donna e del Bambino e della Salute Pubblica, UOC Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy., Greco P; Department of Medical Sciences, Institute of Obstetrics and Gynecology, University of Ferrara, Ferrara, Italy., Driul L; Department of Medicine (DMED), University of Udine, Udine, Italy; Department of Maternal and Child Health, Obstetrics and Gynecology Clinic, Ospedale Santa Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy., Amant F; Department of Development and Regeneration, KU Leuven, Leuven, Belgium; Department of Obstetrics and Gynecology, University Hospitals KU Leuven, Leuven, Belgium., Fagotti A; Dipartimento per la salute della Donna e del Bambino e della Salute Pubblica, UOC Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore, Roma, Italy., Scambia G; Dipartimento per la salute della Donna e del Bambino e della Salute Pubblica, UOC Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy; Università Cattolica del Sacro Cuore, Roma, Italy., Vizzielli G; Department of Medicine (DMED), University of Udine, Udine, Italy; Department of Maternal and Child Health, Obstetrics and Gynecology Clinic, Ospedale Santa Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy., Restaino S; Department of Maternal and Child Health, Obstetrics and Gynecology Clinic, Ospedale Santa Maria della Misericordia, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy; PhD School in Biomedical Sciences, Gender Medicine, Child and Women Health, University of Sassari, Sassari, Italy.
Jazyk: angličtina
Zdroj: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2024 Nov 07; Vol. 51 (1), pp. 109359. Date of Electronic Publication: 2024 Nov 07.
DOI: 10.1016/j.ejso.2024.109359
Abstrakt: Objective: We assessed reproductive, obstetrical, and oncological outcomes in patients who underwent fertility-sparing treatment by including studies that adhere to the FIGO 2018 staging system.
Methods: Data on recurrence, mortality, pregnancy rate, live birth rate, and preterm delivery rate were collected.
Results: In patients with stages IA1, IA2, and IB1, the recurrence rate was 4.7 % and the death rate was 0.6 %. For patients with stage IB2, the recurrence rate was 12.1 % and the death rate was 3.2 %. Pregnancy rates for conization/simple trachelectomy and radical trachelectomy were 61.7 % and 50 %, respectively. A higher live birth rate (84.4 % vs 58.6 %), and lower preterm birth rate (18.3 % vs 33.3 %) were observed in patients undergoing conization compared to radical trachelectomy.
Conclusion: We found a recurrence rate of 4.7 % in patients with stage less than or equal to IB1 and 12.1 % in those with stage IB2. A higher rate of preterm delivery was observed in patients who underwent radical trachelectomy.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
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