Link Between Metabolic Syndrome, Blood Lipid Markers, Dietary Lipids, and Survival in Women with Early-Stage Breast Cancer.

Autor:	Bobin-Dubigeon C; Nantes Université CNRS, US2B, UMR 6286, 44000 Nantes, France.; ICO René Gauducheau, Bd Jacques Monod, 44805 Nantes Saint Herblain CEDEX, France.; Centre de Recherche en Nutrition Humaine Ouest (CRNH), 44093 Nantes, France., Campion L; ICO René Gauducheau, Bd Jacques Monod, 44805 Nantes Saint Herblain CEDEX, France., Bossard C; Nantes Université CNRS, US2B, UMR 6286, 44000 Nantes, France.; Centre de Recherche en Nutrition Humaine Ouest (CRNH), 44093 Nantes, France., Rossignol E; ICO René Gauducheau, Bd Jacques Monod, 44805 Nantes Saint Herblain CEDEX, France., Frenel JS; ICO René Gauducheau, Bd Jacques Monod, 44805 Nantes Saint Herblain CEDEX, France., Campone M; ICO René Gauducheau, Bd Jacques Monod, 44805 Nantes Saint Herblain CEDEX, France., Bard JM; Centre de Recherche en Nutrition Humaine Ouest (CRNH), 44093 Nantes, France.
Jazyk:	angličtina
Zdroj:	Nutrients [Nutrients] 2024 Oct 22; Vol. 16 (21). Date of Electronic Publication: 2024 Oct 22.
DOI:	10.3390/nu16213579
Abstrakt:	Background/objectives: Nearly 10% of cancers could be prevented through dietary changes. In addition, breast cancer (BC) is the most common cancer in women worldwide. Inadequate diet may lead to several metabolic abnormalities, including metabolic syndrome (MS). The goal of our study is to evaluate the link between survival after BC and MS, as well as diet lipids and circulating lipids. Methods: This study was performed in an early-stage BC cohort (n = 73): MS, dietary lipids, and circulating biological parameters, including leucocyte expression in cholesterol carriers (ATP-binding cassette transporter ABCA1, ABCG1), were determined before any medication intervention. The data of each patient were analyzed using univariate logistic regression and are expressed by HR, 95%CI [5th-95th]. All these parameters were explored with survival parameters using Cox regression analyses. Results: Overall survival (OS) and invasive disease-free survival (iDFS) were significantly longer for the women without metabolic syndrome with HR 4.7 [1.11-19.92] and p = 0.036, and 3.58 [1.23-10.44] and p = 0.019, respectively. The expression of ABCG1 in peripheral leucocytes, an ATP-binding cassette transporter involved in cholesterol and phospholipid trafficking, is significantly associated with iDFS (1.38 [1.1-1.9], p = 0.0048). MS is associated with more pejorative survival parameters in early-stage breast cancer. Paraoxonase (or PON) activities differ according to PON gene polymorphism, but also diet. A link between PON activities and survival parameters was suggested and needs to be clarified. Conclusions: This study emphasizes the link between survival parameters of early-stage breast cancer, metabolic syndrome, and some parameters related to lipid metabolism.
Databáze:	MEDLINE
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