Consent-Related Outcomes in the Alteplase Compared to Tenecteplase Trial.

Autor:	Shamy MC; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Dewar B; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Deschaintre Y; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Singh N; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Kenney C; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Almekhlafi MA; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Ademola A; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Buck BH; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Sajobi TT; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Catanese L; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Sage KD; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Dowlatshahi D; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Gioia LC; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Tkach A; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Swartz RH; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada., Menon BK; From the Department of Medicine (M.C.S., D.D.), University of Ottawa, Ontario; The Ottawa Hospital (M.C.S., D.D.), Ontario; Ottawa Hospital Research Institute (M.C.S., B.D., D.D.), Ontario; Centre Hospitalier de L'Université de Montréal (Y.D., L.C.G.), Quebec; Department of Neurology (N.S.), University of Manitoba, Winnipeg; Department of Clinical Neurosciences (C.K., M.A.A., A.A., K.D.S., B.K.M., T.T.S.), University of Calgary, Alberta; Department of Neurology (B.H.B.), University of Alberta, Edmonton; McMaster University (L.C.), Hamilton, Ontario; Kelowna General Hospital (A.T.), British Columbia; and Sunnybrook Health Sciences Centre (R.H.S.), Toronto, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	Neurology [Neurology] 2024 Nov 26; Vol. 103 (10), pp. e209974. Date of Electronic Publication: 2024 Nov 07.
DOI:	10.1212/WNL.0000000000209974
Abstrakt:	Background and Objectives: In recent years, researchers have sought to address the challenges of obtaining informed consent for participation in acute stroke trials. We studied outcomes related to the use of deferral of consent in the phase 3 Alteplase Compared to Tenecteplase (AcT) trial. Methods: As part of our protocol, we captured methods of consent, participant withdrawals, door-to-randomization times, and door-to-needle times. Participants at 3 sites were invited to complete a survey of attitudes regarding consent for AcT and for acute stroke trials generally. Results: The AcT trial enrolled 1,600 participants from 22 centers across Canada of whom 1,537 were enrolled through deferral of consent (96.0%) and 63 (4.0%) were enrolled by prospective verbal consent followed by written informed consent. Of those enrolled by deferral of consent, 95% (1,454/1,537) consented to ongoing participation. Door-to-randomization times were similar regardless of method of consent, with an overall median of 30 minutes (interquartile range [IQR] 22-42): 29 minutes (IQR 22-42) in the deferral of consent group vs 32 minutes (IQR 25-44) in the prospective consent group ( p = 0.1602). Survey respondents overwhelming agreed or strongly agreed with the use of deferral of consent in AcT (86%) and in any acute stroke trial (76%). Discussion: Deferral of consent was broadly acceptable to participants in the AcT trial as demonstrated by low rates of withdrawal and by survey results. Door-to-randomization times using deferral of consent in AcT were short, although a system of prospective verbal consent used at 1 center took only slightly longer. These results support the importance of innovation around consent for acute stroke trials.
Databáze:	MEDLINE
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