Knowledge and perceptions of South African blood donors towards biobanking and stool donation.

Autor:	Claassen-Weitz S; Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., du Toit E; Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Gardner-Lubbe S; Department of Statistics and Actuarial Sciences, Faculty of Economic and Management Sciences, Stellenbosch University, Stellenbosch, South Africa., Kullin B; Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Bellairs G; Western Cape Blood Services, Cape Town, South Africa., Hilton C; Western Cape Blood Services, Cape Town, South Africa., Chicken A; Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Welp K; Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Livingstone H; Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Brink A; Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa.; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Jazyk:	angličtina
Zdroj:	Southern African journal of infectious diseases [S Afr J Infect Dis] 2024 Oct 31; Vol. 39 (1), pp. 645. Date of Electronic Publication: 2024 Oct 31 (Print Publication: 2024).
DOI:	10.4102/sajid.v39i1.645
Abstrakt:	Background: The complexity of contexts and varied purposes for which biome donation are requested are unknown in South Africa. Objectives: The aim of this study was to provide strategic data towards actualisation of whether a stool donor bank may be established as a collaborative between Western Cape Blood Services (WCBS) and the University of Cape Town (UCT). Method: We designed a cross-sectional, questionnaire-based survey to determine willingness of WCBS blood donors to donate stool specimens for microbiome biobanking. The study was conducted between 01 June 2022 and 01 July 2022 at three WCBS donation centres in Cape Town, South Africa. Anonymous blood donors who met the inclusion criteria were enrolled. Anonymised demographic and interview data were analysed statistically. Results: Analysis of responses from 209/231 blood donors demonstrated in a logistic regression model that compensation ( p < 0.001) and 'societal benefit outweighs inconvenience' beliefs ( p = 7.751e-05) were covariates significantly associated with willingness to donate stool. Age was borderline significant at a 5% level ( p = 0.0556). Most willing stool donors indicated that donating stool samples would not affect blood donations (140/157, 90%). Factors decreasing willingness to donate were stool collection being unpleasant or embarrassing. Conclusion: The survey provides strategic data for the establishment of a stool bank and provided an understanding of the underlying determinants regarding becoming potential donors. Contribution: This is the first report on the perspectives of potential participants in donating samples towards a stool microbiome biobank in South Africa, a necessity for faecal microbiota transplantation (FMT). Competing Interests: The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article. (© 2024. The Authors.)
Databáze:	MEDLINE
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