Adverse food reactions and alterations in nutritional status in children with autism spectrum disorders: results of the NAFRA project.

Autor: Coppola S; Department of Translational Medical Science, University of Naples 'Federico II', Via S. Pansini 5, Naples, 80131, Italy.; CEINGE-Advanced Biotechnologies, ImmunoNutritionLab, University of Naples 'Federico II', Naples, Italy., Nocerino R; Department of Translational Medical Science, University of Naples 'Federico II', Via S. Pansini 5, Naples, 80131, Italy. rita.nocerino@unina.it.; CEINGE-Advanced Biotechnologies, ImmunoNutritionLab, University of Naples 'Federico II', Naples, Italy. rita.nocerino@unina.it.; Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy. rita.nocerino@unina.it., Oglio F; Department of Translational Medical Science, University of Naples 'Federico II', Via S. Pansini 5, Naples, 80131, Italy.; CEINGE-Advanced Biotechnologies, ImmunoNutritionLab, University of Naples 'Federico II', Naples, Italy., Golia P; Department of Translational Medical Science, University of Naples 'Federico II', Via S. Pansini 5, Naples, 80131, Italy., Falco MC; Department of Translational Medical Science, University of Naples 'Federico II', Via S. Pansini 5, Naples, 80131, Italy., Riccio MP; Department of Maternal and Child Health, Child and Adolescent Psychiatry, AOU 'Federico II', Naples, Italy., Carucci L; Department of Translational Medical Science, University of Naples 'Federico II', Via S. Pansini 5, Naples, 80131, Italy.; CEINGE-Advanced Biotechnologies, ImmunoNutritionLab, University of Naples 'Federico II', Naples, Italy., Rea T; Department of Public Health, University of Federico II, Naples, Italy., Simeone S; Department of Clinical and Experimental Medicine, University of Catanzaro Magna Graecia, Catanzaro, Italy., Garotti R; Department of Translational Medical Science, University of Naples 'Federico II', Via S. Pansini 5, Naples, 80131, Italy., Marani N; Department of Translational Medical Science, University of Naples 'Federico II', Via S. Pansini 5, Naples, 80131, Italy., Bravaccio C; Department of Translational Medical Science, University of Naples 'Federico II', Via S. Pansini 5, Naples, 80131, Italy., Canani RB; Department of Translational Medical Science, University of Naples 'Federico II', Via S. Pansini 5, Naples, 80131, Italy.; CEINGE-Advanced Biotechnologies, ImmunoNutritionLab, University of Naples 'Federico II', Naples, Italy.; Task Force on Microbiome Studies, University of Naples 'Federico II', Naples, Italy.; European Laboratory for the Investigation of Food-Induced Diseases, University of Naples 'Federico II', Naples, Italy.
Jazyk: angličtina
Zdroj: Italian journal of pediatrics [Ital J Pediatr] 2024 Nov 04; Vol. 50 (1), pp. 228. Date of Electronic Publication: 2024 Nov 04.
DOI: 10.1186/s13052-024-01794-8
Abstrakt: Background: To assess the adverse food reactions (AFR) prevalence in children with autism spectrum disorder (ASD) and in non-ASD healthy controls (NASD). Nutritional status alterations, food selectivity and adherence to Mediterranean Diet (MD) were also evaluated.
Methods: The NAFRA (Nutritional status and Adverse Food Reactions in children with Autism Spectrum Disorder) project was an observational, case-control, comparative study conducted at a tertriary center for pediatrics involving Caucasian patients of both sexes, aged 18 months-7 years, with a diagnosis of ASD, and matched NASD controls.
Results: From October 2017 to December 2023, 100 ASD patients [79 male, mean (± SD) age 49.9 months (± 15.4)] and 100 NASD controls [75 male, mean (± SD) age 49.8 months (± 17.7)] were enrolled at the Pediatric Section of the Department of Translational Medical Science of the University of Naples Federico II. A significantly higher prevalence of AFR was observed in ASD patients if compared with NASD (16% vs. 2%, p = 0.001), mainly due to a higher prevalence of food allergy (7% vs. 1%, p = 0.03). A significantly higher prevalence of food intolerance and celiac disease was also observed in ASD children. The rate of obesity was significantly higher in ASD patients compared to NASD. Food selectivity and low MD-adherence were more frequent in ASD children (26% vs. 2%, p < 0.0001 and 28% vs. 16%, p = 0.041, respectively).
Conclusions: The high rate of AFR, obesity and unhealthy dietary habits observed in ASD children strongly suggest the importance of a multidisciplinary approach, providing early diagnosis of AFR and appropriate nutritional management to improve core and associated ASD-related conditions.
Trial Registration: The NAFRA Project was registered on https://clinicaltrials.gov/ with the identifier NCT04719923. Registered 18 January 2021. https://clinicaltrials.gov/study/NCT04719923 .
(© 2024. The Author(s).)
Databáze: MEDLINE
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