The role of cholesterol crystals and ocular crystal emboli in retinal pathology.
| Autor: | Medawar NG; University of Alabama at Birmingham, Department of Visual Sciences and Ophthalmology, Birmingham, AL, United States of America., Dorweiler TF; Boston Children's Hospital, Department of Surgery, Cambridge, MA, United States of America., Abela GS; Michigan State University, Department of Medicine, College of Human Medicine, East Lansing, MI, United States of America., Busik JV; University of Oklahoma, Department of Biochemistry and Physiology, Oklahoma City, OK, United States of America., Grant MB; University of Alabama at Birmingham, Department of Visual Sciences and Ophthalmology, Birmingham, AL, United States of America. |
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| Jazyk: | angličtina |
| Zdroj: | American heart journal plus : cardiology research and practice [Am Heart J Plus] 2024 Oct 11; Vol. 47, pp. 100475. Date of Electronic Publication: 2024 Oct 11 (Print Publication: 2024). |
| DOI: | 10.1016/j.ahjo.2024.100475 |
| Abstrakt: | Cholesterol crystals (CC) can be responsible for a range of clinical syndromes in the retina from asymptomatic plaques to retinal artery occlusion with clinical trials providing evidence for the efficacy in lipid lowering therapies in preventing ocular pathology. Much of the literature has focused on CC in retinal circulation as a marker of poor systemic health and have attempted to use them to categorize risk of mortality and stroke. More recently cholesterol accumulation and CC formation have been linked to development of diabetic retinopathy with CC formation in the retina due to aberrant retinal cholesterol homeostasis and not simply systemic dyslipidemia. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The author is an Editorial Board Member/Editor-in-Chief/Associate Editor/Guest Editor for [Journal name] and was not involved in the editorial review or the decision to publish this article. (© 2024 The Authors. Published by Elsevier Inc.) |
| Databáze: | MEDLINE |
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