Modeling the relationship between arterial blood pressure and sublingual microcirculatory blood flow assessed by Sidestream Dark Field videomicroscopy: An experimental study in anesthetized piglets.

Autor: Foulon É; Université de Lyon, UR APCSe Agressions Pulmonaires et Circulatoires dans le Sepsis, VetAgro Sup, 1 avenue Bourgelat, F-69280 Marcy l'Etoile, France; Université de Lyon, VetAgro Sup, Unité de Physiologie, Pharmacodynamie et Thérapeutique, 1 avenue Bourgelat, F-69280 Marcy l'Etoile, France., Bonnet-Garin JM; Université de Lyon, UR APCSe Agressions Pulmonaires et Circulatoires dans le Sepsis, VetAgro Sup, 1 avenue Bourgelat, F-69280 Marcy l'Etoile, France; Université de Lyon, VetAgro Sup, Unité de Physiologie, Pharmacodynamie et Thérapeutique, 1 avenue Bourgelat, F-69280 Marcy l'Etoile, France. Electronic address: jeanne-marie.bonnet@vetagro-sup.fr., Allaouchiche B; Université de Lyon, UR APCSe Agressions Pulmonaires et Circulatoires dans le Sepsis, VetAgro Sup, 1 avenue Bourgelat, F-69280 Marcy l'Etoile, France; Université de Lyon, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Réanimation Médicale, 165 Chemin du Grand Revoyet, F-69310 Pierre-Bénite, France., Junot S; Université de Lyon, UR APCSe Agressions Pulmonaires et Circulatoires dans le Sepsis, VetAgro Sup, 1 avenue Bourgelat, F-69280 Marcy l'Etoile, France; Université de Lyon, VetAgro Sup, Anesthésiologie, 1 avenue Bourgelat, F-69280 Marcy l'Etoile, France. Electronic address: stephane.junot@vetagro-sup.fr., Magnin M; Université de Lyon, UR APCSe Agressions Pulmonaires et Circulatoires dans le Sepsis, VetAgro Sup, 1 avenue Bourgelat, F-69280 Marcy l'Etoile, France; Université de Lyon, VetAgro Sup, Unité de Physiologie, Pharmacodynamie et Thérapeutique, 1 avenue Bourgelat, F-69280 Marcy l'Etoile, France. Electronic address: mathieu.magnin@vetagro-sup.fr.
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2023 Oct 25; Vol. 165, pp. 105068. Date of Electronic Publication: 2023 Oct 25.
DOI: 10.1016/j.rvsc.2023.105068
Abstrakt: Microcirculation is frequently assessed using videomicroscopy in the sublingual mucosa. However, limited research has been conducted on the existence of blood flow autoregulation in this region. We conducted a study in an experimental porcine model of pharmacologically induced hypotension to evaluate the relationship between mean arterial pressure (MAP) and the microvascular flow index (MFI). We hypothesized that this relationship would be linear in the absence of autoregulation or bilinear if autoregulation is present. Seven pigs underwent blood pressure changes induced by norepinephrine (hypertension) and sevoflurane (hypotension) administration. Sublingual microcirculation was assessed using a sidestream dark field device, and videos were recorded at different MAP levels ranging from 30 to 110 mmHg. MFI was calculated using the quadrant-based method. For our first hypothesis, we constructed a linear mixed model, while a bilinear model was used for the second hypothesis. The linear model demonstrated a statistically significant association (P = 0.03) described by the equation: MFI = 2.29 + 0.004 x MAP. The bilinear model identified a statistically significant inflection point at MAP = 99 mmHg (P = 0.01) with MFI = 2.7 AU (P < 0.0001). For MAP <99 mmHg, the relationship was: MFI = 2.26 + 0.004 x MAP, and for MAP >99 mmHg, MFI = 2.7. Despite statistical significance, neither model provided a satisfactory graphical fit due to high inter- and intra-individual variability. Consequently, this study did not allow us to draw conclusions regarding the presence of blood autoregulation.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.
(Copyright © 2023. Published by Elsevier Ltd.)
Databáze: MEDLINE
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