Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities.

Autor: Kwon RH; Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea.; Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju, 54896, Korea., Na H; Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea., Kim JH; Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea., Kim SA; Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea., Kim SY; Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju, 54896, Korea., Jung HA; Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju, 54896, Korea., Lee SH; Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea., Wee CD; Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea., Lee KS; Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea., Kim HW; Department of Agrofood Resources, National Institute of Agricultural Sciences, Rural Development Administration, Wanju, 55365, Republic of Korea. ksharrier@korea.kr.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Nov 01; Vol. 14 (1), pp. 26330. Date of Electronic Publication: 2024 Nov 01.
DOI: 10.1038/s41598-024-77574-5
Abstrakt: Acanthopanax senticosus belongs to Araliaceae family and is traditionally used as a tonic. The roots and stems are mainly used as treatments for hypodynamia, rheumatism, and hypertension, but their frequent use may lead to extinction. However, comprehensive and simultaneous analysis of the remaining parts were still limited. There is a need to reorganize them for standardization of functional foods. In this study, 50 phenolic compounds and 82 triterpenoid saponins from the shoots, leaves, fruits, and stems of were characterized using UPLC-QTOF-MS and UPLC-QTRAP-MS/MS. Among them, 52 compounds were newly determined as the cis and malonyl-bound phenolic acids and were found to be structural isomers of Acanthopanax flavonoids and saponins. All compounds were absolutely/relatively quantified, and shoots had the highest content. Peroxynitrite and α-glucosidase inhibitory activities were performed, followed by evaluation of structure-activity relationships. Particularly, hederasaponin B and ciwujianoside B showed remarkable efficacy, which were affected by the C-23 hydroxylation, the C-20(29) double bond, and the presence of rhamnose. These detailed profiling can be used as fundamental data for increasing the utilization of A. senticosus and developing them into functional foods.
(© 2024. The Author(s).)
Databáze: MEDLINE
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