Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas.

Autor:	Borda V; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA; University of Maryland Institute for Health Computing, University of Maryland School of Medicine, North Bethesda, MD 20852, USA. Electronic address: vicbp1@gmail.com., Loesch DP; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Guo B; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Laboulaye R; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Veliz-Otani D; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA., French JN; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Leal TP; Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH, USA., Gogarten SM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Ikpe S; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Gouveia MH; Center for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA., Mendes M; Department of Genetics, Ecology, and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Abecasis GR; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Alvim I; Department of Genetics, Ecology, and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Arboleda-Bustos CE; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia., Arboleda G; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia., Arboleda H; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia., Barreto ML; Instituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA 40110-040, Brazil., Barwick L; LTRC Data Coordinating Center, The Emmes Company, Rockville, MD, USA., Bezzera MA; Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Recife, PE 50670-901, Brazil., Blangero J; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Borges V; Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil., Caceres O; Instituto Nacional de Salud, Lima, Peru; Facultad de Ciencias de la Salud, Universidad Científica del Sur, Lima, Peru., Cai J; Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Chana-Cuevas P; CETRAM, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago, Chile., Chen Z; Keck School of Medicine, University of Southern California, Los Angeles, Los Angeles, CA, USA., Custer B; Vitalant Research Institute, San Francisco, CA, USA., Dean M; Laboratory of Genomic Diversity, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Rockville, MD, USA., Dinardo C; Instituto de Medicina Tropical, University of São Paulo, São Paulo, Brazil., Domingos I; Department of Genetics, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235, Recife, PE 50670-901, Brazil., Duggirala R; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Dieguez E; Neurology Institute, Universidad de la República, Montevideo, Uruguay., Fernandez W; Neuroscience and Cell Death Research Groups, Medical School and Genetic Institute, Universidad Nacional de Colombia, Bogota, Colombia., Ferraz HB; Movement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, São Paulo, Brazil., Gilliland F; Keck School of Medicine, University of Southern California, Los Angeles, Los Angeles, CA, USA., Guio H; Instituto Nacional de Salud, Lima, Peru; INBIOMEDIC Research Center, Lima, Peru; Universidad de Huánuco, Huánuco, Peru., Horta B; Faculdade de Medicina, Departamento de Medicina Social, Universidade Federal de Pelotas, Pelotas, RS, Brazil., Curran JE; Department of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Johnsen JM; Bloodworks Northwest Research Institute, Seattle, WA, USA., Kaplan RC; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Kelly S; Vitalant Research Institute, San Francisco, CA, USA; UCSF Benioff Children's Hospital, University of California, San Francisco, Oakland, CA, USA., Kenny EE; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Konkle BA; Department of Medicine, University of Washington, Seattle, WA, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Lescano A; Neurology Institute, Universidad de la República, Montevideo, Uruguay., Lima-Costa MF; Instituto de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Meyers DA; Division of Genetics, Genomics, and Precision Medicine, University of Arizona, Tucson, AZ, USA., Naslavsky MS; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil., Nickerson DA; Department of Genome Sciences, University of Washington, Seattle, WA, USA., North KE; Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Padilla C; Instituto Nacional de Salud, Lima, Peru., Preuss M; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Raggio V; Genetics Department, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay., Reiner AP; Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Rieder CR; Departamento de Neurologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brazil., Rienstra M; Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA., Rundek T; Department of Neurology, Miller School of Medicine, and The Evelyn F. McKnight Brain Institute, University of Miami, Miami, FL, USA., Sacco RL; Department of Neurology, Miller School of Medicine, and The Evelyn F. McKnight Brain Institute, University of Miami, Miami, FL, USA., Sanchez C; Instituto Nacional de Salud, Lima, Peru., Sankaran VG; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Santos-Lobato BL; Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Brazil., Schumacher-Schuh AF; Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Serviço de Neurologia, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Scliar MO; Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil., Silverman EK; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Sofer T; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Harvard Medical School, Boston, MA USA., Lasky-Su J; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Tumas V; Ribeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, Brazil., Weiss ST; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Mata IF; University of Maryland Institute for Health Computing, University of Maryland School of Medicine, North Bethesda, MD 20852, USA., Hernandez RD; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA., Tarazona-Santos E; Department of Genetics, Ecology, and Evolution, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Facultad de Salud Pública y Administración. Universidad Peruana Cayetano Heredia, Lima, Peru., O'Connor TD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; Program in Health Equity and Population Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Program in Personalized Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address: timothydoconnor@gmail.com.
Jazyk:	angličtina
Zdroj:	Cell genomics [Cell Genom] 2024 Nov 13; Vol. 4 (11), pp. 100692. Date of Electronic Publication: 2024 Oct 31.
DOI:	10.1016/j.xgen.2024.100692
Abstrakt:	Latin Americans are underrepresented in genetic studies, increasing disparities in personalized genomic medicine. Despite available genetic data from thousands of Latin Americans, accessing and navigating the bureaucratic hurdles for consent or access remains challenging. To address this, we introduce the Genetics of Latin American Diversity (GLAD) Project, compiling genome-wide information from 53,738 Latin Americans across 39 studies representing 46 geographical regions. Through GLAD, we identified heterogeneous ancestry composition and recent gene flow across the Americas. Additionally, we developed GLAD-match, a simulated annealing-based algorithm, to match the genetic background of external samples to our database, sharing summary statistics (i.e., allele and haplotype frequencies) without transferring individual-level genotypes. Finally, we demonstrate the potential of GLAD as a critical resource for evaluating statistical genetic software in the presence of admixture. By providing this resource, we promote genomic research in Latin Americans and contribute to the promises of personalized medicine to more people. Competing Interests: Declaration of interests The authors declare no competing interests. D.P.L. is now an employee of AstraZeneca. This is unrelated to the work of this paper. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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