Meta-analysis of tick-borne and other pathogens: Co-infection or co-detection? That is the question.

Autor:	Porcelli S; ANSES, INRAE, Ecole Nationale Vétérinaire D'Alfort, UMR BIPAR, Laboratoire de Santé Animale, 94700, Maisons-Alfort, France., Deshuillers PL; ANSES, INRAE, Ecole Nationale Vétérinaire D'Alfort, UMR BIPAR, Laboratoire de Santé Animale, 94700, Maisons-Alfort, France., Moutailler S; ANSES, INRAE, Ecole Nationale Vétérinaire D'Alfort, UMR BIPAR, Laboratoire de Santé Animale, 94700, Maisons-Alfort, France., Lagrée AC; ANSES, INRAE, Ecole Nationale Vétérinaire D'Alfort, UMR BIPAR, Laboratoire de Santé Animale, 94700, Maisons-Alfort, France.
Jazyk:	angličtina
Zdroj:	Current research in parasitology & vector-borne diseases [Curr Res Parasitol Vector Borne Dis] 2024 Oct 05; Vol. 6, pp. 100219. Date of Electronic Publication: 2024 Oct 05 (Print Publication: 2024).
DOI:	10.1016/j.crpvbd.2024.100219
Abstrakt:	This literature-based review aims to distinguish studies describing co-infection with tick-borne pathogens from those describing co-detection or co-exposure scenarios. The review analyzed 426 papers and identified only 20 with direct evidence of co-infection in humans and animals, highlighting the need for accurate terminology and proposing definitions for co-infection, co-exposure and co-detection. Current diagnostic methods - including serology and molecular techniques - have limitations in accurately identifying real co-infections, often leading to misinterpretation. The review highlights the importance of developing laboratory models to better understand tick-borne pathogen interactions, and advocates improved diagnostic strategies for tick screening by testing their RNA for co-infections. Moreover, the establishment of additional animal models for pathogen co-infection will help develop our understanding of selection pressures for various traits of tick-borne pathogens (such as virulence and transmissibility) over time. This comprehensive analysis provides insights into the complexity of tick-borne pathogen co-infections and calls for precise diagnostic terms to improve the clarity and effectiveness of future research. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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