Accuracy of COVID-19 diagnostic tests via infrared spectroscopy: A systematic review and meta-analysis.

Autor: Cobre AF; Pharmaceutical Sciences Postgraduate Program, Universidade Federal do Paraná, Curitiba, Brazil; School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, United Kingdom., Fachi MM; Pharmaceutical Sciences Postgraduate Program, Universidade Federal do Paraná, Curitiba, Brazil., Domingues KZA; Pharmaceutical Sciences Postgraduate Program, Universidade Federal do Paraná, Curitiba, Brazil., Lazo REL; Pharmaceutical Sciences Postgraduate Program, Universidade Federal do Paraná, Curitiba, Brazil., Ferreira LM; Department of Pharmacy, Pharmaceutical Sciences Postgraduate Program, Universidade Federal do Paraná, Curitiba, Brazil., Tonin FS; H&TRC - Health & Technology Research Centre, ESTeSL, Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, Lisbon, Portugal., Pontarolo R; Department of Pharmacy, Pharmaceutical Sciences Postgraduate Program, Universidade Federal do Paraná, Curitiba, Brazil. Electronic address: pontarolo@ufpr.br.
Jazyk: angličtina
Zdroj: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy [Spectrochim Acta A Mol Biomol Spectrosc] 2024 Oct 28; Vol. 327, pp. 125337. Date of Electronic Publication: 2024 Oct 28.
DOI: 10.1016/j.saa.2024.125337
Abstrakt: This study aims to synthesize the evidence on the accuracy parameters of COVID-19 diagnosis methods using infrared spectroscopy (FTIR). A systematic review with searches in PubMed and Embase was performed (September 2023). Studies reporting data on test specificity, sensitivity, true positive, true negative, false positive, and false negative using different human samples were included. Meta-analysis of accuracy estimates with 95 % confidence intervals and area under the ROC Curve (AUC) were conducted (Meta-Disc 1.4.7). Seventeen studies were included - all of them highlighted regions 650-1800 cm -1 and 2300-3900 cm -1 as most important for diagnosing COVID-19. The FTIR technique presented high sensitivity [0.912 (95 %CI, 0.878-0.939), especially in vaccinated [0.959 (CI95 %, 0.908-0.987)] compared to unvaccinated [0.625 (CI95 %, 0.584-0.664)] individuals for COVID-19. Overall specificity was also high [0.886 (95 %CI, 0.855-0.912), with increased rates in vaccinated [0.884 (CI95 %, 0.819-0.932)] than in unvaccinated [0.667 (CI95 %, 0.629-0.704)] patients. These findings reveal that FTIR is an accurate technique for detecting SARS-CoV-2 infection in different biological matrices with advantages including low cost, rapid and environmentally friendly with minimal preparation analyses. This could lead to an easy implementation of this technique in practice as a screening tool for patients with suspected COVID-19, especially in low-income countries.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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